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Anti-hLAL immunohistochemical staining of lal−/−;MMR+/+ (A and C) and lal−/−;MMR−/− (B and D) mouse kidneys. Kidney sections from PBS-injected mice (A and B) and hLAL-injected mice (C and D) were processed for immunohistochemical staining by use of anti-hLAL antibody. Only lal−/−;MMR−/− mice had positive uptake of hLAL in kidneys and only in the proximal renal tubular epithelial cells (D). Original magnification, ×200.
