Table 1.

Detailed dosing and administration of FIA+VEN regimen with intermittent hemodialysis. Adjustments made according to renal function, performance status, age, and concomitant medications.

Chemotherapy	Induction dosing and administration€	Consolidation cycles 2 and 4¥
Fludarabine	15 mg/m2 IV on days 1–3, starting daily at 0530	15 mg/m2 IV on days 1–3, starting daily at 1900
Idarubicin	6 mg/m2 IV on days 1 and 2, administered at 0700	N/A
Cytarabine	400 mg/m2 on days 1–3; infused over 3 hours, starting 3 hours after completion of fludarabine at 0900	400 mg/m2 on days 1–3; infused over 3 hours, starting 3 hours after completion of fludarabine at 2200
Venetoclax	50 mg PO on day 2, followed by 100 mg PO on day 3 and 200 mg PO on days 4–6; target dose 400 mg reduced for concomitant amiodarone	100 mg daily on days 1–3; target dose 400 mg reduced due to concomitant voriconazole
Hemodialysis	Daily C1D1–C1D4 starting 6 hours after completion of cytarabine infusion at 1800; duration and volume of ultrafiltration tailored to volume status and laboratory studies	Daily D2–4 starting at 0800

^€ Timing approximated to nearest half hour.

^¥ C3 consolidation chemotherapy timing and intermittent hemodialysis (IHD) administration as per induction.