Table 2.

Percentage of flagged antibodies for each therapeutic antibody profiling (TAP) metric.

Descriptor	Acceptable region	Percentage of flagged antibodies for each metric [Number of antibodies provided in brackets]
		Target A paired [70]	Target A combinatorial [23]	Target B paired [84]	Target B combinatorial [21]
Patches of surface hydrophobicity (PSH)	82.8 < x < 127.8	5.7% [4]	8.7% [2]	9.5% [8]	0% [0]
Patches of positive charge (PPC)	x < 1.29	0% [0]	0% [0]	0% [0]	4.8% [1]
Patches of negative charge (PNC)	x < 1.98	4.2% [3]	8.7% [2]	0% [0]	4.8% [1]
Structural Fv charge symmetry parameter (SFvCSP)	x >  − 6	2.9% [1]	4.3% [1]	0% [0]	4.8% [1]
CDR length	x < 60	0% [0]	0% [0]	0% [0]	0%
Total unique, flagged antibodies		12.8% [9]	21.7% [5]	9.5% [8]	14.3% [3]