Table 2.
Axillary dose parameters in INSEMA randomization-2 patients treated with postoperative whole-breast irradiation after breast-conserving surgery (per-protocol set)
| Parameter | cALND N = 169 |
SLNB alone N = 217 |
Overall N = 386 |
P value | |
|---|---|---|---|---|---|
| Axillary level I dose median (% of breast dose in Gy) | Mean | 78.9 | 78.5 | 78.7 | 0.989 |
| SD | 32.7 | 32.0 | 32.3 | ||
| Median | 94.6 | 95.0 | 94.8 | ||
| Q1–Q3 | 83.5–97.8 | 77.9–98.0 | 79.6–98.0 | ||
| Missing | 44 | 45 | 89 | ||
| Axillary level I dose average (% of breast dose in Gy) | Mean | 73.7 | 75.6 | 74.8 | 0.997 |
| SD | 30.9 | 27.5 | 29.0 | ||
| Median | 88.5 | 84.9 | 86.8 | ||
| Q1–Q3 | 68.0–95.0 | 65.7–95.2 | 65.7–95.2 | ||
| Missing | 36 | 40 | 76 | ||
| Axillary level II dose median (% of breast dose in Gy) | Mean | 59.2 | 56.0 | 57.4 | 0.307 |
| SD | 40.8 | 40.3 | 40.5 | ||
| Median | 81.7 | 74.6 | 77.2 | ||
| Q1–Q3 | 10.1–97.3 | 8.7–95.6 | 9.4–96.4 | ||
| Missing | 43 | 45 | 88 | ||
| Axillary level II dose average (% of breast dose in Gy) | Mean | 60.8 | 55.6 | 57.9 | 0.154 |
| SD | 36.8 | 36.3 | 36.5 | ||
| Median | 72.0 | 68.6 | 69.6 | ||
| Q1–Q3 | 27.0–96.6 | 16.9–91.6 | 18.7–95.0 | ||
| Missing | 35 | 41 | 76 | ||
| Axillary level III dose median (% of breast dose in Gy) | Mean | 46.0 | 35.3 | 39.8 | 0.223 |
| SD | 45.3 | 41.3 | 43.3 | ||
| Median | 11.7 | 9.3 | 10.0 | ||
| Q1–Q3 | 3.6–97.6 | 3.2–87.9 | 3.4–95.2 | ||
| Missing | 43 | 45 | 88 | ||
| Axillary level III dose average (% of breast dose in Gy) | Mean | 47.3 | 38.1 | 42.0 | 0.155 |
| SD | 43.0 | 38.9 | 40.9 | ||
| Median | 26.6 | 22.1 | 23.0 | ||
| Q1–Q3 | 6.0–96.4 | 4.1–85.2 | 4.8–93.8 | ||
| Missing | 36 | 41 | 77 | ||
Q1 first quartile, Q3 third quartile, SD standard deviation, SLNB sentinel lymph node biopsy, cALND completion axillary lymph node dissection, Gy Gray.