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. 2026 Jan 19;45:102445. doi: 10.1016/j.bbrep.2026.102445

Fig. 2.

Fig. 2

BRCA2 overexpression alleviated cardiac hypertrophy. a, BRCA2 overexpression inhibited the expansion of cardiocytes in the heart of mice induced by Ang II. b, BRCA2 overexpression inhibited the increases of HW, HW/BW, HW/TL, LW/BW, IVSs, IVSd LVPWs, LVPWd, LVAWs and LVAWd induced by Ang II of mice. c, BRCA2 overexpression inhibited the increases of ANP, BNP and β-MHC induced by Ang II in the heart of mice. d, BRCA2 overexpression inhibited the increases of ANP, BNP and β-MHC induced by Ang II in the cultured NRCMs. The results were expressed as mean ± SEM. n = 8 (a–c) or 6 (d) for each group. One-way ANOVA was used. Bars, 100 μm. BRCA2, breast cancer susceptibility gene 2; Ang II, angiotensin II; HW, heart weight; BW, body weight; TL, tibia length; IVSs, end-systolic interventricular septal thickness; IVSd, end-diastolic interventricular septal thickness; LVPWs, left ventricular posterior wall thickness in systole; LVPWd, left ventricular posterior wall thickness in diastole; LVAWs, left ventricular anterior wall thickness in systole; LVAWd, left ventricular anterior wall thickness in diastole; ANP, atrial natriuretic peptide; BNP, b-type natriuretic peptide; β-MHC, β-myosin heavy chain; NRCMs, neonatal rat cardiomyocytes.