Fig. 3.

BRCA2 overexpression alleviated cardiac fibrosis. a, BRCA2 overexpression inhibited the cardiac fibrosis induced by Ang II of mice. b, BRCA2 overexpression inhibited the increases of collagen I, collagen III and TGF-β induced by Ang II in the heart of mice. c, BRCA2 overexpression inhibited the increases of collagen I, collagen III and TGF-β induced by Ang II in the cultured NRCFs. The results were expressed as mean ± SEM. n = 8 for each group. One-way ANOVA was used. Bars, 100 μm. BRCA2, breast cancer susceptibility gene 2; Ang II, angiotensin II; TGF-β, transforming growth factor β; NRCFs, neonatal rat cardiac fibroblasts.