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. 2026 Jan 19;45:102445. doi: 10.1016/j.bbrep.2026.102445

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© 2026 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — BRCA2 overexpression alleviated inflammation of hypertrophic cardiomyopathy. a, BRCA2 overexpression inhibited the increase of IL-1β induced by Ang II in the heart of mice through immunofluorescence detection. b, BRCA2 overexpression inhibited the increase of IL-6 induced by Ang II in the heart of mice through immunofluorescence detection. c, BRCA2 overexpression inhibited the increase of TNF-α induced by Ang II in the heart of mice through immunofluorescence detection. d, BRCA2 overexpression inhibited the increase of IL-1β, IL-6 and TNF-α induced by Ang II in the heart of mice through ELISA detection. The results were expressed as mean ± SEM. n = 8 for each group. One-way ANOVA was used. Bars, 100 μm. BRCA2, breast cancer susceptibility gene 2; Ang II, angiotensin II; IL-1β, interleukin-1beta; IL-6, interleukin-6; TNF-α, tumor necrosis factor-alpha; ELISA, enzyme-linked immunosorbent assay. Arrows, IL-1β (a), IL-6 (b) or TNF-α (c).