Table 3.
Associations of Healthy Sleep Pattern With All-Cause Mortality and Mediation Proportion Attributed to Atherosclerotic Cardiovascular Disease
| Sleep Pattern | n (%) | Events/Person-Years | HR (95% CI) |
Mediation Proportion,b % (95% CI) | P Value | |
|---|---|---|---|---|---|---|
| Without Mediators (Total Effect) | With Mediators (Direct effect)a | |||||
| Healthy sleep | 89,507 (60.2%) | 3,198/362,495.4 | Reference | Reference | ||
| Intermediate sleep | 42,597 (28.7%) | 1,689/169,006.4 | 1.20 (1.11-1.30) | 1.17 (1.08-1.27) | 11.2 (5.6-21.1) | 0.0001 |
| Poor sleep | 16,518 (11.1%) | 756/65,274.1 | 1.28 (1.18-1.39) | 1.24 (1.14-1.35) | 12.6 (7.9-19.6) | <0.001 |
HRs and corresponding 95% CIs are provided for the total and direct effects. Models are adjusted for age, sex, ancestry, marital status, educational attainment, smoking status, alcohol consumption, physical activity, chronic condition, body mass index categories, and survey year. Mediation analysis was conducted via the SAS MEDIATE Macro (https://ysph.yale.edu/cmips/research/software/analysis-graphics/mediate/).
a
Direct effect obtained from a model including atherosclerotic cardiovascular disease.
b
Proportion of the association mediated by atherosclerotic cardiovascular disease.