Fig. 1.

Trajectory of clinical sepsis subtypes. Left column are patients with highest subtype membership probabilities (“core patients”). The right lighter shaded column are patients with lower membership probabilities (“margin patients”). Upper panels A and B show the proportion of subjects in original subtype in 6-h intervals from presentation to 48 h after arrival. Lower panels C and D illustrate a heat map of transition patterns. Green is α-type, purple is β-type, red is γ-type, and blue is δ-type. Core patients have >90% membership probability for their assigned clinical sepsis subtype, and margin patients with <90% membership probability.