Fig. 3.

Odds of clinical sepsis subtype change in 48 h after presentation. Panel A shows odds ratio (95% confidence intervals) for logistic regression model in observational data (n = 36,591), with interaction between initial subtype and core vs. margin strata (interaction p < 0.01). Panel B reports a similar model and interaction in ProCESS trial data (n = 821), adjusting for randomised treatment arm. Dark circles to the left of 1.0 correspond to a reduced adjusted odds of changing subtype, and to the right an increased adjusted odds of changing subtype. Patients in core have >90% membership probability for their assigned clinical sepsis subtype, and patients in margin have <90% membership probability.