Table 2.
LSS and CTS Cases Versus Controls: Competing Risk Regression Models for Cardiac Events of Interest
| Models | Cardiac Event of Interest |
|||
|---|---|---|---|---|
| CHF | AF/AFL | PM/ICD | Any Cardiac Event of Interesta | |
| LSS cohort | ||||
| M1b: LSS case (vs control) csHR (95% CI) | 1.50 (1.47-1.53) | 1.33 (1.31-1.35) | 1.55 (1.50-1.61) | 1.26 (1.25-1.28) |
| 10-year rate (SD) | ||||
| LSS cases | 22.5% (0.7%) | 44.3% (0.9%) | 5.5% (0.4%) | 36.3% (0.9%) |
| Controls | 14.0% (0.4%) | 34.5% (0.5%) | 3.3% (0.2%) | 26.9% (0.5%) |
| M2b: Controls csHR (95% CI) | Reference | Reference | Reference | Reference |
| 10-year rate (SD) | 14.0% (0.4%) | 34.5% (0.5%) | 3.3% (0.2%) | 26.9% (0.5%) |
| LSS case with diagnosis (no procedure) | ||||
| csHR (95% CI) | 1.55 (1.51-1.58) | 1.31 (1.29-1.33) | 1.56 (1.50-1.62) | 1.28 (1.26-1.30) |
| 10-year rate (SD) | 23.1% (0.8%) | 43.7% (1.0%) | 5.5% (0.4%) | 36.8% (1.0%) |
| LSS case with procedure | ||||
| csHR (95% CI) | 1.32 (1.25-1.39) | 1.40 (1.35-1.45) | 1.53 (1.44-1.62) | 1.20 (1.15-1.24) |
| 10-year rate (SD) | 19.8% (1.5%) | 46.8% (2.0%) | 5.2% (0.8%) | 34.5% (1.9%) |
| CTS cohort | ||||
| M3b: CTS case (vs control) csHR (95% CI) | 1.42 (1.40-1.45) | 1.34 (1.32-1.36) | 1.36 (1.31-1.40) | 1.26 (1.24-1.28) |
| 10-year rate (SD) | ||||
| CTS cases | 15.4% (0.6%) | 33.0% (0.8%) | 3.6% (0.3%) | 24.3% (0.8%) |
| Controls | 10.6% (0.3%) | 24.9% (0.4%) | 2.5% (0.1%) | 17.9% (0.4%) |
| M4b: Controls csHR (95% CI) | Reference | Reference | Reference | Reference |
| 10-year rate (SD) | 10.6% (0.3%) | 24.9% (0.4%) | 2.5% (0.3%) | 17.9% (0.4%) |
| CTS case with diagnosis (no procedure) | ||||
| csHR (95% CI) | 1.44 (1.41-1.48) | 1.35 (1.32-1.37) | 1.28 (1.23-1.33) | 1.29 (1.27-1.32) |
| 10-year rate (SD) | 15.5% (0.7%) | 31.8% (1.0%) | 3.6% (0.4%) | 24.6% (0.9%) |
| CTS case with procedure | ||||
| csHR (95% CI) | 1.39 (1.39-1.43) | 1.33 (1.29-1.37) | 1.50 (1.41-1.59) | 1.21 (1.17-1.24) |
| 10-year rate (SD) | 15.0% (0.9%) | 35.1% (1.4%) | 3.6% (0.5%) | 23.6% (1.3%) |
Table values reflect the cause-specific HR (csHR) of the case in relation to the age- and sex-matched controls. Cumulative incidences are calculated with death as a competing risk and only patients who did not have a prior history of the cardiac event of interest are included.
CHF = congestive heart failure; other abbreviations as in Table 1.
a
CHF, AF/AFL, and/or PM/ICD implantation.
b
P < 0.001.