Figure 2.

Septic shock triggers a remodeling of fatty-acyls chains in triacylglycerols (TGs) and phospholipids. (A) Dot-plot of glycerophospholipid remodeling in septic shock patients compared with controls. The Y-axis displays 1 fatty acyl chain of phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), and phosphatidylinositols (PIs), while the X-axis shows the other fatty acyl chain. The intensity of the dot color is proportional to the Log₂FC in signal intensity between groups, with upregulated lipids in red and downregulated lipids in blue. Dot size reflects adjusted P values calculated using the Benjamini–Hochberg method, with larger dots indicating statistical significance (FDR < 0.05). (B) Forest plot of platelet PCs and PEs, comparing septic shock and control patients. Each line on the Y-axis represents a PC or PE species. The X-axis shows the Log₂FC of peak intensities for each species, comparing septic shock and control groups. Horizontal lines indicate the 95% CI. Only significantly altered species, with a |Log₂FC| ≥ 0.5, are represented, with statistical significance defined as an adjusted P value of <0.05. (C) Dot-plot of TG remodeling in septic shock patients compared with controls. Similar to (A), but here, the Y-axis displays the degree of unsaturation (number of double bounds), while the X-axis indicates the carbon chain length. (D) Forest plot of platelet TGs, comparing septic shock and control patients. Similar to (B) but showing the Log₂FC of significantly altered TG species.