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. 2025 Dec 12;302(2):111047. doi: 10.1016/j.jbc.2025.111047

Figure 1.

Figure 1

Loss of biosynthetic capacity for α2-6-sialoglycans minimally influences cell death receptor expression on a model T cell line.A, ST6GAL1-/- Jurkat cells were generated using CRISPR/Cas9 and phenotyped via flow cytometry. B, presentation of α2-6-sialoglycans and their corresponding asialo-N-acetygalactosamine counterparts was measured on WT and ST6GAL1−/− Jurkat cells using the fluorescent lectins from Sambucus Nigra (SNA) and Erythrina Cristagalli (ECL), respectively. C, expression of the TNF receptor superfamily members TRAIL-R1, TNFR1, and FasR on WT and ST6GAL1−/− Jurkat cells. D, quantification of data from C. Results are reported as mean SD from three experiments. ∗p < 0.05, ns = p > 0.05 = not significant, student’s t test, two-tailed.