Table 1. Examples of delivery vectors and chemical modifications of PNA oligonucleotides.
| Serial number | PNA backbone | Delivery platforms | Uptake mechanism | Treated in vivo/in vitro |
|---|---|---|---|---|
| 1 [ref. 16, 19 and 51] |
|
|
Endocytosis | In vitro cell assays |
| 2 [ref. 64, 67, 73 and 74] |
|
|
Endocytosis | In vitro and in vivo assays |
| 3 [ref. 78 and 79] |
|
|
Receptor mediated uptake | In vitro and in vivo assays |
| 4 [ref. 6, 8, 84, 86 and 89] |
|
|
Endocytosis | In vitro and in vivo assays |
| 5 [ref. 100] |
|
|
Endocytosis | In vitro cell assays |
| 6 [ref. 102] |
|
|
Endocytosis | In vitro cell assays |