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. 2026 Jan 16;17:1737852. doi: 10.3389/fgene.2026.1737852

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Copyright © 2026 Ni, Gu, Wang, Zhang, Zhou, Zhang, Gao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three dot plots labeled A, B, and C depict pathways against the rich factor. Plot A (3M vs 1M) shows thyroid hormone signaling pathway as prominent. Plot B (6M vs 3M) highlights focal adhesion. Plot C (8M vs 6M) emphasizes axon guidance. Dot size represents count and color indicates -log10(p-value), with red and larger dots signifying higher values. — The top 20 significant KEGG pathways of miRNA-targeted mRNAs in the three comparisons. (A) KEGG pathways in the M3 vs. M1 comparison; (B) KEGG pathways in the M6 vs. M3 comparison; (C) KEGG pathways in the M8 vs. M6 comparison.