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. 2026 Jan 16;17:1737852. doi: 10.3389/fgene.2026.1737852

FIGURE 7.

Panel A shows the TCF3 wild type and mutant sequences aligned with ssc-miR-1343, displaying partial complementarities. Panel B presents bar graphs of relative luciferase activity comparing mimics NC and ssc-miR-1343 mimics for TCF3-Wt and TCF3-Mut, indicating a significant difference for TCF3-Wt. Panel C shows the FASN wild type and mutant sequences aligned with ssc-miR-1343, showing partial complementarities. Panel D presents similar bar graphs for FASN-Wt and FASN-Mut, also showing a significant difference for FASN-Wt.

Validation of TCF3 and FASN as direct targets of ssc-miR-1343. (A) The information of ssc-miR-1343 and TCF3 interaction and their binding sites; (B) Validation of the targeting relationship between ssc-miR-1343 and TCF3 by using dual-luciferase reporter assay; (C) The information of ssc-miR-1343 and FASN interaction and their binding sites; (D) Validation of the targeting relationship between ssc-miR-1343 and FASN by using dual-luciferase reporter assay. Error bars indicate the mean ± standard deviation of triplicate experiments, *** indicate p-value < 0.001.