Table 2.

Effect of MCT Inhibitors on Generation of γH2AX in the Presence of Colibactin 686 (9)^a

inhibitor	none	MCT1	MCT4	MCT1/4
cell line		AZD-3965 (100 μM)	VB-124 (100 μM)	syrosingopine (10 μM)
HeLa	190 ± 20 nM	26 ± 2 nM	104 ± 8 nM	18 ± 3 nM
MDA-MB231	26 ± 3 nM	15 ± 3 nM	8.1 ± 1.7 nM	4.3 ± 1.6 nM

^aValues reported are the concentration of colibactin 686 (9) required to achieve ≥10 γH2AX foci in 50% of the cell population.