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. 2026 Jan 23;83(1):79. doi: 10.1007/s00018-025-06040-w

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Supplementation with recombinant BMP6 alleviates PE-related phenotypes in the Ad Flt1-induced PE rat model. An SD rat model of PE was established as described in Fig. 5A. Pregnant rats were randomly divided into four groups: the Ad Fc + PBS, Ad Fc + BMP6, Ad Flt1 + PBS, and Ad Flt1 + BMP6 groups. A, BMP6 supplementation rescues the increased blood pressure in the Ad Flt1-induced PE rat model. SBP and MAP of pregnant rats in each group (n = 4). B-C, BMP6 supplementation rescues fetal growth restriction and placental hypoefficiency in the Ad Flt1-induced PE rat model. B, Representative images of fetal rats and placentas from each group at G19 (n = 7). C, Weights of fetal rats and corresponding placental efficiency at G19 in the Ad Fc + PBS group (n = 33), Ad Fc + BMP6 group (n = 39), Ad Flt1 + PBS group (n = 32), and Ad Flt1 + BMP6 group (n = 47). D-F, BMP6 supplementation alleviates placental damage in the Ad Flt1-induced PE rat model. D, HE staining of rat placentas was performed to observe the placental labyrinth and junction areas. Representative images are presented in the left panel, and the placental labyrinth/junction ratios in each group were quantified and summarized in the right panel (n = 8). Scale bar, 3 mm. E, Immunohistochemistry localization of CD34 in rat placenta on G19. Representative images are presented in the left panel, and the ratios of CD34-positive area were quantified and are summarized in the right panel. Scale bar, 100 μm. F, Immunohistochemistry localization of α-SMA in the rat uterus on G19. Scale bar, 100 μm. Representative images are presented in the left panel, and the ratios of un-remodeled blood vessels were quantified and are summarized in the right panel. The quantitative results are expressed as the means ± SEMs of at least three independent experiments. Two-way ANOVA was used for data comparison. Groups without common letters are significantly different from each other (P < 0.05). SD, Sprague–Dawley; SBP, systolic blood pressure; MAP, mean arterial pressure; PBS, phosphate-buffered saline; Ad Fc, adenovirus-expressing control IgG2a Fc fragment; Ad Flt1, adenovirus expressing fms-like tyrosine kinase-1; LZ, labyrinth zone; JZ, junction zone