Table 2.
Change from baseline in each cytokine by group and time, mean (95% CI) ( p value)
| Cytokine | T-APA | NT-APA | CG | |||||
|---|---|---|---|---|---|---|---|---|
| T2 (n = 64) |
M1 (n = 50) |
M3 (n = 39) |
T2 (n = 57) |
M1 (n = 45) |
M3- (n = 34) |
T2 (n = 52) |
M1 (n = 45) |
|
| Pro-inflammatory | ||||||||
| IFNg | -0.15 (-0.28, -0.02) (0.02) | -0.03 (-0.32, 0.26) (0.86) | -0.07 (-0.50, 0.35) (0.72) | 0.20 (-0.01, 0.41) (0.07) | 0.21 (-0.09, 0.51) (0.16) | 0.28 (-0.04, 0.59) (0.08) | 0.20 (-0.07, 0.46) (0.14) | 0.06 (-0.24, 0.36) (0.70) |
| IL-12(p40) | -0.11 (-0.22, -0.00) (0.05) | -0.03 (-0.19, 0.13) (0.74) | -0.12 (-0.37, 0.12) (0.32) | -0.06 (-0.28, 0.16) (0.57) | 0.08 (-0.16, 0.32) (0.51) | -0.16 (-0.52, 0.20) (0.38) | 0.06 (-0.16, 0.27) (0.60) | 0.07 (-0.16, 0.29) (0.56) |
| IL-12(p70) | -0.04 (-0.11, 0.03) (0.24) | 0.03 (-0.14, 0.19) (0.75) | 0.14 (-0.18, 0.46) (0.38) | 0.14 (-0.10, 0.38) (0.24) | 0.20 (-0.07, 0.47) (0.15) | 0.12 (0.01, 0.23) (0.03) | 0.12 (-0.12, 0.35) (0.32) | 0.09 (-0.24, 0.42) (0.58) |
| IL-17 A | -0.03 (-0.10, 0.03) (0.31) | 0.01 (-0.04, 0.05) (0.69) | 0.11 (-0.09, 0.32) (0.26) | -0.02 (-0.15, 0.11) (0.75) | 0.00 (-0.09, 0.10) (0.96) | -0.05 (-0.22, 0.11) (0.50) | 0.03 (-0.03, 0.09) (0.35) | 0.06 (-0.02, 0.14) (0.16) |
| IL-1a | -0.04 (-0.14, 0.06) (0.41) | 0.06 (-0.05, 0.18) (0.25) | 0.09 (-0.10, 0.29) (0.34) | 0.02 (-0.15, 0.19) (0.82) | 0.07 (-0.08, 0.22) (0.37) | -0.07 (-0.29, 0.16) (0.56) | 0.06 (-0.06, 0.18) (0.34) | 0.03 (-0.10, 0.15) (0.67) |
| IL-1b | -0.06 (-0.16, 0.04) (0.21) | -0.03 (-0.18, 0.12) (0.67) | -0.02 (-0.24, 0.20) (0.87) | 0.06 (-0.18, 0.30) (0.61) | 0.14 (-0.06, 0.34) (0.16) | -0.06 (-0.26, 0.13) (0.53) | 0.08 (-0.07, 0.24) (0.28) | 0.08 (-0.15, 0.30) (0.49) |
| IL-6 | -0.07 (-0.26, 0.12) (0.48) | 0.15 (-0.07, 0.38) (0.18) | -0.18 (-0.42, 0.06) (0.14) | 0.35 (0.10, 0.61) (0.01) | 0.29 (0.01, 0.56) (0.05) | 0.33 (-0.05, 0.71) (0.08) | 0.03 (-0.16, 0.23) (0.75) | 0.16 (-0.19, 0.52) (0.36) |
| IL-8 | -0.15 (-0.29, -0.01) (0.04) | -0.10 (-0.29, 0.09) (0.29) | -0.13 (-0.36, 0.10) (0.27) | 0.09 (-0.07, 0.25) (0.26) | 0.11 (-0.13, 0.35) (0.37) | 0.21 (-0.08, 0.51) (0.15) | 0.12 (-0.01, 0.25) (0.07) | 0.02 (-0.23, 0.26) (0.90) |
| TNFa | -0.05 (-0.11, 0.00) (0.06) | -0.02 (-0.14, 0.11) (0.81) | -0.06 (-0.27, 0.15) (0.58) | 0.10 (-0.05, 0.24) (0.19) | 0.17 (-0.03, 0.37) (0.09) | 0.04 (-0.16, 0.23) (0.71) | 0.13 (-0.04, 0.30) (0.12) | 0.13 (-0.11, 0.37) (0.30) |
| IL-2 | -0.11 (-0.22, -0.00) (0.04) | 0.04 (-0.11, 0.20) (0.57) | -0.02 (-0.32, 0.29) (0.90) | 0.03 (-0.21, 0.27) (0.79) | 0.27 (-0.02, 0.55) (0.07) | 0.03 (-0.28, 0.34) (0.85) | 0.16 (-0.03, 0.35) (0.10) | 0.20 (-0.04, 0.43) (0.10) |
| Anti-inflammatory | ||||||||
| IL-4 | -0.09 (-0.20, 0.03) (0.15) | 0.03 (-0.11, 0.17) (0.63) | -0.00 (-0.19, 0.19) (0.97) | 0.15 (-0.01, 0.30) (0.06) | 0.16 (-0.09, 0.41) (0.20) | 0.26 (0.05, 0.46) (0.01) | 0.13 (-0.04, 0.31) (0.13) | -0.12 (-0.38, 0.14) (0.35) |
| IL-10 | 0.03 (-0.10, 0.16) (0.63) | 0.09 (-0.11, 0.29) (0.36) | 0.03 (-0.14, 0.20) (0.74) | 0.02 (-0.16, 0.21) (0.80) | 0.05 (-0.19, 0.29) (0.68) | 0.07 (-0.34, 0.48) (0.74) | 0.14 (-0.05, 0.33) (0.14) | 0.03 (-0.18, 0.23) (0.80) |
| IL-13 | -0.02 (-0.11, 0.07) (0.68) | 0.06 (-0.16, 0.28) (0.58) | -0.04 (-0.34, 0.26) (0.80) | 0.16 (-0.00, 0.33) (0.05) | 0.19 (-0.07, 0.44) (0.14) | 0.09 (-0.09, 0.28) (0.32) | 0.05 (-0.14, 0.23) (0.60) | 0.02 (-0.24, 0.28) (0.88) |
| TGFb | 0.62 (0.04, 1.20) (0.04) | 0.06 (-0.69, 0.81) (0.87) | -0.12 (-1.06, 0.83) (0.80) | 0.58 (0.03, 1.13) (0.04) | 0.24 (-0.57, 1.06) (0.55) | 0.42 (-0.51, 1.35) (0.37) | 0.31 (-0.27, 0.89) (0.29) | -0.00 (-0.61, 0.61) (0.99) |
p values are not adjusted for multiplicity. Observations lower than the detection limit were substituted by one-half of the corresponding lower detection limit; Boldface values indicate p <0.05