Table 2.

Adverse life experiences and symptom-based trajectories of pain, depression, anxiety, and comorbidities.

	Coef	SE	T	Pval	R2	Adj R2	CI [2.5%]	CI [97.5%]	VIF	Pval_corrected
ALEs and high-level symptom-based trajectories
Pain
Physical_illness_child FU1	0.029	0.009	3.402	0.001	0.143	0.094	0.012	0.046	5.640213	0.039
Total ALE score FU2	0.022	0.007	3.024	0.003	0.025	0.02	0.008	0.036	5.111497	0.015
Abuse and maltreatment—Factor1	0.023	0.006	3.570	0.000	0.025	0.021	0.010	0.036	1.860628	0.000
Depression
Sexual_abuse	0.023	0.006	4.120	0.000	0.097	0.055	0.012	0.034	1.209255	0.000
BullyingBL	0.028	0.006	4.765	0.000	0.097	0.055	0.016	0.039	1.590381	0.000
Total ALE score FU1	0.016	0.005	2.934	0.003	0.016	0.012	0.005	0.027	6.084844	0.015
Anxiety
BullyingBL	0.034	0.008	4.513	0.000	0.111	0.07	0.019	0.049	1.590381	0.000
Total ALE score FU1	0.023	0.007	3.425	0.001	0.034	0.031	0.010	0.037	6.084844	0.005
Total ALE score FU2	0.018	0.007	2.677	0.008	0.034	0.031	0.005	0.031	4.457266	0.040
ALEs and moderate-level symptom-based trajectories
Pain
BullyingFU1	0.060	0.014	4.300	0.000	0.111	0.059	0.033	0.087	1.419223	0.000
Total ALE score FU1	0.048	0.014	3.348	0.001	0.047	0.043	0.020	0.076	8.055105	0.005
Depression
Parents_violentFU1	−0.035	0.010	−3.349	0.001	0.085	0.043	−0.056	−0.015	1.892365	0.039
Total ALE score FU3	0.031	0.009	3.531	0.000	0.02	0.017	0.014	0.048	4.478934	0.000
Factor 2	0.019	0.006	3.023	0.003	0.021	0.018	0.007	0.031	3.706052	0.015
Anxiety
BullyingFU3	0.041	0.012	3.485	0.001	0.09	0.048	0.018	0.063	1.198944	0.039
Material, health, and emotional deprivation—Factor 2	0.041	0.010	4.192	0.000	0.019	0.016	0.022	0.061	3.706052	0.000
ALEs and symptom-based trajectories of pain comorbidities
Pain–depression comorbidities
Substance abuse in the household FU2	0.021	0.006	3.409	0.001	0.065	0.019	0.009	0.033	1.304255	0.039
Abuse and maltreatment—Factor1	0.015	0.004	3.453	0.001	0.018	0.014	0.007	0.024	1.880138	0.005
Pain–anxiety comorbidities
Material, health, and emotional deprivation—Factor 2	0.015	0.006	2.662	0.008	0.019	0.015	−0.004	0.027	3.635520	0.040
Pain–depression–anxiety comorbidities
Material, health, and emotional deprivation—Factor 2	0.011	0.004	3.008	0.003	0.016	0.013	0.004	0.018	3.680576	0.015

The regression models for ALEs categories at all time points BL (Baseline), FU1 (Follow-up 1), FU2 (Follow-up 2), FU3 (Follow-up 3) and the high and moderate symptoms classes of pain, depression, and anxiety and comorbidities. The table reports only results that retained statistical significance after correction. For high symptom trajectories, physical illness, bullying, sexual abuse, total ALE scores, and specific factors emerged as significant for pain, depression, and anxiety. Moderate symptom trajectories revealed again that bullying, parental violence, total ALE scores, and abuse and maltreatment factor were also significant, with distinct patterns for each symptom. Pain–depression comorbidities were significantly associated with household substance abuse and abuse-maltreatment factor. Pain–anxiety comorbidities were linked to deprivation-related factors, as well as the combined pain–depression–anxiety comorbidity. These findings underscore the differentiated pathways through which ALEs contribute to comorbid symptom development. Full details and expanded analyses are provided in Supplement, http://links.lww.com/PR9/A380. In the corresponding order Coefficients, Standard Errors, T-values, P-values, R-squared, Adjusted R-squared, Confidence Intervals, VIF, and Bonferroni-corrected P-values. Age ranges for participants at each time point were 14 to 15 y (BL), with follow-ups at 16 to 17 (FU1), 18 to 19 (FU2), and 22 to 24 (FU3). Bold font indicates statistically significant P-values.

ALE, adverse life experiences; VIF, variance inflation factor.