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. 2025 Dec 31;17:204. doi: 10.1007/s12672-025-04302-4

Table 2.

Proteolysis targeting chimeras (PROTACs) targeting ER

Compound E3 ligase E3 ligand Reference​
ARV-471 CRBN Lenalidomide [269]
ERD-308 VHL VHL032 derivative [270]
ERD-148 VHL VHL032 derivative [271]
PROTAC-2 SCF IκBα​​​ [272]
PROTAC-B VHL HIF-1 alpha [273]
SNIPER(ER)-3 CIAP Bestatin amide [274]
SNIPER(ER)-87 XIAP LCL161 derivative [275]