Table 2.
MRI semantic feature comparisons between idhmut and IDHwt groups
| Characteristics | Cohort A: Training set & Internal validation set | Cohort B: External testing set | ||||
|---|---|---|---|---|---|---|
| IDHmut (n = 227) | IDHwt (n = 40) | P | IDHmut (n = 66) | IDHwt (n = 31) | P | |
| Location | < 0.001ξ | < 0.001ξ | ||||
| Frontal | 157 (69.16) | 10 (25.00) | 42 (63.64) | 9 (29.03) | ||
| Temporal-insular | 56 (24.67) | 6 (15.00) | 19 (28.79) | 6 (19.35) | ||
| Parieto-occipital | 12 (5.29) | 5 (12.50) | 4 (6.06) | 7 (22.58) | ||
| Other | 2 (0.88) | 19 (47.50) | 1 (1.51) | 9 (29.04) | ||
| RT2FM | < 0.001ξ | < 0.001Ψ | ||||
| Present | 220 (96.92) | 14 (35.00) | 61 (92.42) | 18 (58.06) | ||
| Absent | 7 (3.08) | 26 (65.00) | 5 (7.58) | 13 (41.94) | ||
| Multifocal/Multicentric | < 0.001ξ | < 0.001Ψ | ||||
| Present | 8 (3.52) | 22 (55.00) | 5 (7.58) | 11 (35.48) | ||
| Absent | 219 (96.48) | 18 (45.00) | 61 (92.42) | 20 (64.52) | ||
| Deep WM invasion | < 0.001ξ | 0.001Ψ | ||||
| Present | 10 (4.41) | 14 (35.00) | 7 (10.61) | 12 (38.71) | ||
| Absent | 217 (95.59) | 26 (65.00) | 59 (89.39) | 19 (61.29) | ||
| Cyst (s) | 0.642Ψ | 0.708ξ | ||||
| Present | 47 (20.70) | 7 (17.50) | 5 (7.58) | 3 (9.68) | ||
| Absent | 180 (79.30) | 33 (82.50) | 61 (92.42) | 28 (90.32) | ||
| Cortical involvement | < 0.001ξ | 0.032ξ | ||||
| Present | 224 (98.68) | 31 (77.50) | 64 (96.97) | 26 (83.87) | ||
| Absent | 3 (1.32) | 9 (22.50) | 2 (3.03) | 5 (16.13) | ||
| T2WI homogeneity | < 0.001Ψ | 0.046Ψ | ||||
| Homogeneous | 23 (10.13) | 13 (32.50) | 13 (19.70) | 12 (38.71) | ||
| Heterogeneous | 204 (89.87) | 27 (67.50) | 53 (80.30) | 19 (61.29) | ||
| Tumor border | < 0.001Ψ | 0.001Ψ | ||||
| Well defined | 96 (42.29) | 4 (10.00) | 36 (54.55) | 6 (19.35) | ||
| Poorly defined | 131 (57.71) | 36 (90.00) | 30 (45.45) | 25 (80.65) | ||
| Hyperintensity on T1WI | 0.032Ψ | |||||
| Present | 65 (28.63) | 5 (12.50) | 21 (31.82) | 1 (3.23) | 0.002Ψ | |
| Absent | 162 (71.37) | 35 (87.50) | 45 (68.18) | 30 (96.77) | ||
| SWITW | 0.016Ψ | |||||
| Present | 56 (24.67) | 3 (7.50) | 22 (33.33) | 4 (12.90) | 0.034Ψ | |
| Absent | 171 (75.33) | 37 (92.50) | 44 (66.67) | 27 (87.10) | ||
Note. — Unless otherwise indicated, data are numbers of patients, and data in parentheses are percentages. IDH = isocitrate dehydrogenase, IDHmut = IDH mutant, IDHwt = IDH wild type, T1WI = T1 weighted imaging, T2WI = T2 weighted imaging, FLAIR = fluid-attenuated inversion recovery, RT2FM = relaxed T2-FLAIR mismatch, Deep WM invasion = deep white matter invasion, SWITW = sinuous wave-like intratumoral-wall
ξFisher’s exact test
ΨPearson’s Chi-squared test