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Database/Source
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Search Query
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Filters/Limits
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Date Searched
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Number of Results
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PubMed/MEDLINE
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(keratoconus[MeSH Terms] OR keratoconus[Title/Abstract] OR "keratoconus"[Title/Abstract]) AND ("Cross-Linking Reagents/therapeutic use"[MeSH Terms] OR "corneal collagen cross-linking"[Title/Abstract] OR "corneal cross-linking"[Title/Abstract] OR CXL[Title/Abstract] OR "cross linking"[Title/Abstract] OR "collagen cross linking"[Title/Abstract] OR "riboflavin UVA"[Title/Abstract] OR "riboflavin ultraviolet"[Title/Abstract] OR "photoactivated chromophore"[Title/Abstract]) AND (accelerated[Title/Abstract] OR conventional[Title/Abstract] OR Dresden[Title/Abstract] OR "transepithelial"[Title/Abstract] OR "epi-on"[Title/Abstract] OR "epi off"[Title/Abstract] OR "epithelium-off"[Title/Abstract] OR "epithelium-on"[Title/Abstract] OR pulsed[Title/Abstract] OR customized[Title/Abstract] OR iontophoresis[Title/Abstract] OR protocol*[Title/Abstract])
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Humans;
Article types: Clinical Trial, Randomized Controlled Trial, Comparative Study, Observational Study;
Publication dates: 2013 onward
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January 1, 2013 to December 26, 2025
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55
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Embase
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#1: 'keratoconus'/exp OR keratoconus:ti,ab,kw
#2: ('corneal collagen cross linking'/exp OR 'cross linking'/exp OR cxl:ti,ab,kw OR "corneal cross-linking":ti,ab,kw OR "collagen cross linking":ti,ab,kw OR "riboflavin UVA":ti,ab,kw OR "riboflavin ultraviolet":ti,ab,kw OR "photoactivated chromophore":ti,ab,kw)
#3: (accelerated:ti,ab,kw OR conventional:ti,ab,kw OR dresden:ti,ab,kw OR transepithelial:ti,ab,kw OR "epi-on":ti,ab,kw OR "epi off":ti,ab,kw OR "epithelium-off":ti,ab,kw OR "epithelium-on":ti,ab,kw OR pulsed:ti,ab,kw OR customized:ti,ab,kw OR iontophoresis:ti,ab,kw OR protocol*:ti,ab,kw)
#4: #1 AND #2 AND #3
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Humans;
Evidence-based medicine (e.g., RCTs, controlled trials);
Publication types: articles, conference abstracts;
Dates: 2013 to December 2025
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January 1, 2013 to December 26, 2025
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65
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Cochrane CENTRAL
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Adapted queries emphasizing comparative terms and protocol variants (similar to PubMed and Embase)
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Humans;
Clinical trials and comparative studies;
Publication dates: 2013 onward
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January 1, 2013 to December 26, 2025
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28
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Scopus
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Adapted queries emphasizing comparative terms and protocol variants (similar to PubMed and Embase)
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Humans;
Articles, reviews, conference papers;
Publication dates: 2013 onward
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January 1, 2013 to December 26, 2025
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43
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Grey Literature (ClinicalTrials.gov)
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Keywords: "keratoconus cross-linking comparison"
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No specific filters;
Focused on ongoing and completed trials
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January 1, 2013 to December 26, 2025
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4
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Hand-Searching
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Reviewing reference lists of recent reviews and meta-analyses (e.g., Deshmukh et al., 2023 [9]; Kobashi et al., 2020 [12])
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N/A
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N/A
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5
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Deduplication
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N/A
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N/A
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N/A
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34 duplicates removed
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Overall (Post-Deduplication)
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Combined from all databases, exported in NBIB format
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N/A
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N/A
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166 unique sources
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