Table 2.
Associations between plasma fatty acids and incidence of MVDsa
| Variable | Range (% TFA) | Cases/N | HR (95% CI) | ||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||
| SFAs | |||||
| Q1 | <32.74 | 1560/22159 | Reference | Reference | Reference |
| Q2 | 32.74-33.87 | 1572/22148 | 0.98 (0.92–1.05) | 0.99 (0.92–1.06) | 0.99 (0.92–1.06) |
| Q3 | 33.88-35.12 | 1670/22130 | 1.01 (0.94–1.08) | 1.01 (0.94–1.09) | 1.03 (0.96–1.11) |
| Q4 | > 35.12 | 1935/22134 | 1.14 (1.06–1.22) | 1.10 (1.02–1.17) | 1.11 (1.04–1.19) |
| Ptrend | <0.001 | 0.09 | 0.006 | ||
| MUFAs | |||||
| Q1 | <21.53 | 1245/22154 | Reference | Reference | Reference |
| Q2 | 21.53–23.12 | 1425/22151 | 1.08 (1.00–1.16) | 1.02 (0.95–1.10) | 1.00 (0.92–1.08) |
| Q3 | 23.13–25.06 | 1798/22137 | 1.31 (1.22–1.41) | 1.19 (1.10–1.28) | 1.08 (1.00–1.16) |
| Q4 | >25.06 | 2269/22129 | 1.70 (1.58–1.83) | 1.46 (1.36–1.58) | 1.17 (1.09–1.26) |
| Ptrend | <0.001 | <0.001 | <0.001 | ||
| Total PUFAs | |||||
| Q1 | <40.46 | 2250/22148 | Reference | Reference | Reference |
| Q2 | 40.46–43.11 | 1740/22133 | 0.77 (0.72–0.82) | 0.81 (0.76–0.86) | 0.86 (0.81–0.92) |
| Q3 | 43.12–45.21 | 1480/22143 | 0.69 (0.64–0.73) | 0.76 (0.71–0.81) | 0.86 (0.80–0.92) |
| Q4 | >45.21 | 1267/22147 | 0.62 (0.57–0.66) | 0.70 (0.65–0.75) | 0.81 (0.75–0.87) |
| Ptrend | <0.001 | <0.001 | <0.001 | ||
| n-3 PUFAs | |||||
| Q1 | <3.35 | 1541/22136 | Reference | Reference | Reference |
| Q2 | 3.35–4.19 | 1660/22141 | 0.98 (0.91–1.05) | 1.00 (0.93–1.07) | 0.96 (0.90–1.03) |
| Q3 | 4.19–5.19 | 1748/22138 | 0.95 (0.89–1.02) | 0.99 (0.93–1.06) | 0.94 (0.88–1.01) |
| Q4 | >5.19 | 1788/22156 | 0.86 (0.80–0.92) | 0.93 (0.86–0.99) | 0.89 (0.83–0.96) |
| Ptrend | <0.001 | 0.052 | 0.003 | ||
| n-6 PUFAs | |||||
| Q1 | <36.11 | 2276/22144 | Reference | Reference | Reference |
| Q2 | 36.11–38.70 | 1791/22138 | 0.79 (0.74–0.84) | 0.83 (0.78–0.88) | 0.90 (0.84–0.96) |
| Q3 | 38.70–40.74 | 1500/22149 | 0.73 (0.68–0.77) | 0.79 (0.74–0.84) | 0.90 (0.84–0.96) |
| Q4 | >40.74 | 1170/22140 | 0.66 (0.61–0.70) | 0.72 (0.67–0.78) | 0.85 (0.79–0.91) |
| Ptrend | <0.001 | <0.001 | 0.001 | ||
aPtrend was calculated by assigning median values to each quartile and treating it as a continuous variable in the models to test for a linear association across categories. All statistical tests were two-sided. “Cases” refers to the number of incident MVDs cases within each quartile, and “N” represents the total number of participants in that quartile.
Model 1: adjusted for age, sex, ethnicity, deprivation index, and education level.
Model 2: adjusted for model 1 plus dietary score, alcohol, smoking status, physical activity.
Model 3: adjusted for model 2 plus eGFR, dyslipidemia, hypertension, and type 2 diabetes.