Table 4.
Regional comparison of combined genetic risk and prevalence of haemochromatosis in white British across England
| Region | Prevalence (%) | Genetic risk (%) | Ratio |
|---|---|---|---|
| Cheshire & Merseyside | 0.345 | 0.542 | 1.57 |
| London | 0.195 | 0.376 | 1.93 |
| E-Midlands | 0.157 | 0.388 | 2.48 |
| Manchester | 0.214 | 0.532 | 2.49 |
| W-Midlands | 0.162 | 0.421 | 2.60 |
| Southwest | 0.131 | 0.356 | 2.72 |
| East | 0.133 | 0.364 | 2.74 |
| Cornwall | 0.159 | 0.441 | 2.78 |
| Yorkshire | 0.167 | 0.467 | 2.79 |
| Lancashire & S Cumbria | 0.188 | 0.525 | 2.80 |
| Southeast | 0.130 | 0.366 | 2.82 |
| North | 0.160 | 0.519 | 3.24 |
| Birmingham | 0.127 | 0.427 | 3.36 |
Prevalence is the raw prevalence in each region; genetic risk is calculated as the product of the penetrances and genotype frequencies, summed for p.Cys282Tyr homozygotes and p.Cys282Tyr/p.His63Asp heterozygotes; both are given as %. Penetrances for males were used for this calculation.