FIG. 6.

Rapamycin abolishes infection with amphotropic murine leukemia virus (A-MLV)- and vesicular stomatitis virus envelope glycoprotein G (VSV-G)-pseudotyped HIV-1 particles. CHCD4 cells (10⁵) were infected with HXB-Luc and HIV-1 pseudotypes (10 ng of p24) and either left untreated or treated with rapamycin (1.1 nM). Cells were kept in culture for a total of 72 h before monitoring luciferase activity. Results shown are the means ± standard deviation of quadruplicate samples and are representative of at least three independent experiments.