Table 1.
Tumor growth inhibition (TGI) rates from days 0 to day 9
| Group | PBS | circRNAE7E6 1 μg |
circRNAE7E6 3 μg |
circRNAE7E6 10 μg |
|
|---|---|---|---|---|---|
| N# | 6 | 6 | 6 | 6 | |
| Day 0 | Tumor volume (mm3) | 95.16 ± 5.91 | 95.31 ± 5.72 | 95.19 ± 5.31 | 95.46 ± 5.4 |
| TGI (%) | - | - | - | - | |
| Day 2 | Tumor volume (mm3) | 222.70 ± 36.28 | 170.85 ± 21.91 | 154.49 ± 13.89 | 144.56 ± 13.64 |
| TGI (%) | - | 23.41 | 30.65 | 35.30 | |
| Day 4 | Tumor volume (mm3) | 442.71 ± 50.14 | 332.75 ± 31.94 | 284.42 ± 20.92 | 256.51 ± 30.19 |
| TGI (%) | - | 24.96 | 35.78 | 42.24 | |
| Day 7 | Tumor volume (mm3) | 851.14 ± 128.93 | 554.43 ± 109.78 | 477.97 ± 44.18* | 353.66 ± 69.92** |
| TGI (%) | - | 34.96 | 43.87 | 58.58 | |
| †Day 9 | Tumor volume (mm3) | 1462.41 ± 277.21 | 511.41 ± 205.81**** | 498.35 ± 83.91**** | 345.16 ± 91.38**** |
| TGI (%) | - | 65.08 | 65.93 | 76.47 | |
Data are presented as means ± SEMs, Statistical significance was analyzed using one-way ANOVA with multiple comparisons between the PBS control and circRNAE7E6 treatment groups
N#: number of mice per group
†Day 9: The day when mice in the control group began to reach the humane endpoint owing to a high tumor burden
*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001