Table 2.
Multipoint Score |
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Two-Point Score |
Parametric |
Nonparametric |
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Model, Marker, and Age Group (No.)a | LOD | θ | LOD | HLOD | α | NPL | P |
Dominant: | |||||||
D12S1045 (160.7 cM): | |||||||
All (94) | 1.76 | .14 | −3.29 | .57 | .26 | .48 | .31 |
<66 years (50) | 1.89 | .10 | −1.66 | .57 | .31 | .72 | .23 |
⩾66 years (44) | .09 | .26 | −1.62 | .04 | .16 | −.07 | .52 |
<61 years (16) | 1.05 | .04 | −.05 | .30 | .50 | .58 | .27 |
D14S588 (75.6 cM): | |||||||
All (94) | 1.74 | .10 | −2.21 | .71 | .31 | .43 | .33 |
<66 years (50) | 1.03 | .10 | −1.97 | .36 | .27 | .70 | .24 |
⩾66 years (44) | .71 | .08 | −.25 | .38 | .41 | −.12 | .54 |
<61 years (16) | 1.68 | .00 | −.61 | .17 | .34 | .67 | .25 |
D10S1223 (156.3 cM): | |||||||
All (94) | 1.68 | .08 | −1.32 | .96 | .39 | 1.61 | .06 |
<66 years (50) | 2.35 | .02 | 1.41 | 1.79 | .69 | 1.45 | .08 |
⩾66 years (44) | .00 | .50 | −2.73 | .00 | .01 | .81 | .21 |
<61 years (16) | .51 | .00 | 1.00 | 1.00 | .93 | .61 | .26 |
ATA34E08b (33.0 cM): | |||||||
All (94) | .65 | .18 | −2.91 | .29 | .25 | 1.30 | .10 |
<66 years (50) | .00 | .50 | −4.02 | .00 | .01 | .01 | .48 |
⩾66 years (44) | 3.02 | .00 | 1.12 | 1.14 | .82 | 1.89 | .03 |
<61 years (16) | .17 | .18 | −.52 | .14 | .37 | .33 | .36 |
D9S925 (32.2 cM): | |||||||
All (94) | .04 | .30 | −4.08 | .03 | .08 | .21 | .41 |
<66 years (50) | .72 | .12 | −1.36 | .27 | .28 | .67 | .24 |
⩾66 years (44) | .00 | .50 | −2.72 | .00 | .00 | −.41 | .65 |
<61 years (16) | 1.60 | .00 | 1.14 | 1.14 | 1.00 | 1.43 | .08 |
D6S1019 (53.8 cM): | |||||||
All (94) | .03 | .36 | −4.24 | .28 | .19 | .49 | .30 |
<66 years (50) | .00 | .50 | −5.55 | .00 | .00 | −.52 | .69 |
⩾66 years (44) | 1.62 | .00 | 1.31 | 1.35 | .79 | 1.28 | .10 |
<61 years (16) | .00 | .50 | −1.83 | .00 | .00 | −.04 | .50 |
Recessive: | |||||||
D10S1223 (156.3 cM): | |||||||
All (94) | 2.46 | .04 | −.23 | 1.15 | .48 | 1.61 | .06 |
<66 years (50) | 1.28 | .06 | .68 | 1.02 | .62 | 1.45 | .08 |
⩾66 years (44) | 1.17 | .02 | −.91 | .26 | .31 | .81 | .21 |
<61 years (16) | .35 | .02 | .08 | .26 | .54 | .61 | .26 |
D8S2324 (94.1 cM): | |||||||
All (94) | 2.17 | .10 | −3.92 | .18 | .16 | −.05 | .51 |
<66 years (50) | .51 | .18 | −4.17 | .00 | .00 | −1.00 | .84 |
⩾66 years (44) | 2.05 | .00 | .25 | .82 | .50 | 1.00 | .16 |
<61 years (16) | .04 | .26 | −1.54 | .00 | .00 | .06 | .46 |
D1S1656 (245.1): | |||||||
All (94) | 1.99 | .12 | −5.26 | .05 | .09 | .33 | .36 |
<66 years (50) | 1.46 | .10 | −2.87 | −.01 | .02 | .01 | .48 |
⩾66 years (44) | .61 | .16 | −4.23 | .00 | .01 | −.45 | .66 |
<61 years (16) | .30 | .10 | −1.63 | .00 | .00 | −1.24 | .90 |
D16S748 (22.7 cM): | |||||||
All (94) | 1.58 | .12 | −2.68 | .28 | .23 | 1.12 | .13 |
<66 years (50) | 1.22 | .10 | −1.40 | .13 | .22 | .80 | .21 |
⩾66 years (44) | .42 | .18 | −1.28 | .15 | .25 | .78 | .21 |
<61 years (16) | .10 | .12 | −1.20 | .00 | .00 | −.53 | .69 |
D12S1045 (160.7 cM): | |||||||
All (94) | 1.14 | .16 | −6.14 | .01 | .05 | .48 | .31 |
<66 years (50) | 1.71 | .08 | −2.44 | .17 | .19 | .72 | .23 |
⩾66 years (44) | .00 | .50 | −3.71 | .00 | .00 | −.07 | .52 |
<61 years (16) | .51 | .04 | −.88 | .00 | .11 | .58 | .27 |
D15S652 (90.0 cM): | |||||||
All (94) | 1.04 | .16 | −1.10 | .72 | .38 | 1.23 | .11 |
<66 years (50) | .06 | .30 | −2.80 | .00 | .00 | −.23 | .58 |
⩾66 years (44) | 1.65 | .02 | 1.70 | 1.76 | .81 | 2.04 | .03 |
<61 years (16) | .27 | .12 | −.08 | .20 | .49 | .67 | .24 |
ATA34E08b (33.0 cM): | |||||||
All (94) | .38 | .24 | −3.44 | .12 | .17 | 1.30 | .10 |
<66 years (50) | .00 | .50 | −4.42 | .00 | .00 | .01 | .48 |
⩾66 years (44) | 1.58 | .04 | .98 | 1.18 | .68 | 1.89 | .03 |
<61 years (16) | .00 | .50 | −1.61 | .00 | .00 | .33 | .36 |
D2S1790 (103.2 cM): | |||||||
All (94) | .29 | .26 | −4.63 | .27 | .18 | −.01 | .49 |
<66 years (50) | .30 | .20 | −2.21 | .22 | .22 | −.18 | .56 |
⩾66 years (44) | .04 | .32 | −2.43 | .07 | .14 | .18 | .42 |
<61 years (16) | 1.58 | .00 | .72 | .78 | .74 | .45 | .31 |
Markers are ordered on the basis of two-point LOD scores in all families; positions are from the Marshfield map (Broman et al. 1998; also see the Center for Medical Genetics, Marshfield Medical Research Foundation, Web site). The 16 families with mean age <61 years are a subset of the 50 early-onset families.
On chromosome 11.