Table 2.

Two-Point and Multipoint LOD Scores, for Dominant and Recessive Models, and NPL Scores for All Regions of Interest (Two-point LOD Score ⩾1.5)

			Multipoint Score
	Two-Point Score		Parametric			Nonparametric
Model, Marker, and Age Group (No.)a	LOD	θ	LOD	HLOD	α	NPL	P
Dominant:
D12S1045 (160.7 cM):
All (94)	1.76	.14	−3.29	.57	.26	.48	.31
<66 years (50)	1.89	.10	−1.66	.57	.31	.72	.23
⩾66 years (44)	.09	.26	−1.62	.04	.16	−.07	.52
<61 years (16)	1.05	.04	−.05	.30	.50	.58	.27
D14S588 (75.6 cM):
All (94)	1.74	.10	−2.21	.71	.31	.43	.33
<66 years (50)	1.03	.10	−1.97	.36	.27	.70	.24
⩾66 years (44)	.71	.08	−.25	.38	.41	−.12	.54
<61 years (16)	1.68	.00	−.61	.17	.34	.67	.25
D10S1223 (156.3 cM):
All (94)	1.68	.08	−1.32	.96	.39	1.61	.06
<66 years (50)	2.35	.02	1.41	1.79	.69	1.45	.08
⩾66 years (44)	.00	.50	−2.73	.00	.01	.81	.21
<61 years (16)	.51	.00	1.00	1.00	.93	.61	.26
ATA34E08b (33.0 cM):
All (94)	.65	.18	−2.91	.29	.25	1.30	.10
<66 years (50)	.00	.50	−4.02	.00	.01	.01	.48
⩾66 years (44)	3.02	.00	1.12	1.14	.82	1.89	.03
<61 years (16)	.17	.18	−.52	.14	.37	.33	.36
D9S925 (32.2 cM):
All (94)	.04	.30	−4.08	.03	.08	.21	.41
<66 years (50)	.72	.12	−1.36	.27	.28	.67	.24
⩾66 years (44)	.00	.50	−2.72	.00	.00	−.41	.65
<61 years (16)	1.60	.00	1.14	1.14	1.00	1.43	.08
D6S1019 (53.8 cM):
All (94)	.03	.36	−4.24	.28	.19	.49	.30
<66 years (50)	.00	.50	−5.55	.00	.00	−.52	.69
⩾66 years (44)	1.62	.00	1.31	1.35	.79	1.28	.10
<61 years (16)	.00	.50	−1.83	.00	.00	−.04	.50
Recessive:
D10S1223 (156.3 cM):
All (94)	2.46	.04	−.23	1.15	.48	1.61	.06
<66 years (50)	1.28	.06	.68	1.02	.62	1.45	.08
⩾66 years (44)	1.17	.02	−.91	.26	.31	.81	.21
<61 years (16)	.35	.02	.08	.26	.54	.61	.26
D8S2324 (94.1 cM):
All (94)	2.17	.10	−3.92	.18	.16	−.05	.51
<66 years (50)	.51	.18	−4.17	.00	.00	−1.00	.84
⩾66 years (44)	2.05	.00	.25	.82	.50	1.00	.16
<61 years (16)	.04	.26	−1.54	.00	.00	.06	.46
D1S1656 (245.1):
All (94)	1.99	.12	−5.26	.05	.09	.33	.36
<66 years (50)	1.46	.10	−2.87	−.01	.02	.01	.48
⩾66 years (44)	.61	.16	−4.23	.00	.01	−.45	.66
<61 years (16)	.30	.10	−1.63	.00	.00	−1.24	.90
D16S748 (22.7 cM):
All (94)	1.58	.12	−2.68	.28	.23	1.12	.13
<66 years (50)	1.22	.10	−1.40	.13	.22	.80	.21
⩾66 years (44)	.42	.18	−1.28	.15	.25	.78	.21
<61 years (16)	.10	.12	−1.20	.00	.00	−.53	.69
D12S1045 (160.7 cM):
All (94)	1.14	.16	−6.14	.01	.05	.48	.31
<66 years (50)	1.71	.08	−2.44	.17	.19	.72	.23
⩾66 years (44)	.00	.50	−3.71	.00	.00	−.07	.52
<61 years (16)	.51	.04	−.88	.00	.11	.58	.27
D15S652 (90.0 cM):
All (94)	1.04	.16	−1.10	.72	.38	1.23	.11
<66 years (50)	.06	.30	−2.80	.00	.00	−.23	.58
⩾66 years (44)	1.65	.02	1.70	1.76	.81	2.04	.03
<61 years (16)	.27	.12	−.08	.20	.49	.67	.24
ATA34E08b (33.0 cM):
All (94)	.38	.24	−3.44	.12	.17	1.30	.10
<66 years (50)	.00	.50	−4.42	.00	.00	.01	.48
⩾66 years (44)	1.58	.04	.98	1.18	.68	1.89	.03
<61 years (16)	.00	.50	−1.61	.00	.00	.33	.36
D2S1790 (103.2 cM):
All (94)	.29	.26	−4.63	.27	.18	−.01	.49
<66 years (50)	.30	.20	−2.21	.22	.22	−.18	.56
⩾66 years (44)	.04	.32	−2.43	.07	.14	.18	.42
<61 years (16)	1.58	.00	.72	.78	.74	.45	.31

^aMarkers are ordered on the basis of two-point LOD scores in all families; positions are from the Marshfield map (Broman et al. 1998; also see the Center for Medical Genetics, Marshfield Medical Research Foundation, Web site). The 16 families with mean age <61 years are a subset of the 50 early-onset families.

^bOn chromosome 11.