Table 2 Continued.

Two-Point and Multipoint LOD Scores, for Dominant and Recessive Models, and NPL Scores for All Regions of Interest (Two-point LOD Score ⩾1.5)

			Multipoint Score
	Two-Point Score		Parametric			Nonparametric
Model, Marker, and Age Group (No.)a	LOD	θ	LOD	HLOD	α	NPL	P
D12S1045 (160.7 cM):
All (94)	1.14	.16	−6.14	.01	.05	.48	.31
<66 years (50)	1.71	.08	−2.44	.17	.19	.72	.23
⩾66 years (44)	.00	.50	−3.71	.00	.00	−.07	.52
<61 years (16)	.51	.04	−.88	.00	.11	.58	.27
D15S652 (90.0 cM):
All (94)	1.04	.16	−1.10	.72	.38	1.23	.11
<66 years (50)	.06	.30	−2.80	.00	.00	−.23	.58
⩾66 years (44)	1.65	.02	1.70	1.76	.81	2.04	.03
<61 years (16)	.27	.12	−.08	.20	.49	.67	.24
ATA34E08b (33.0 cM):
All (94)	.38	.24	−3.44	.12	.17	1.30	.10
<66 years (50)	.00	.50	−4.42	.00	.00	.01	.48
⩾66 years (44)	1.58	.04	.98	1.18	.68	1.89	.03
<61 years (16)	.00	.50	−1.61	.00	.00	.33	.36
D2S1790 (103.2 cM):
All (94)	.29	.26	−4.63	.27	.18	−.01	.49
<66 years (50)	.30	.20	−2.21	.22	.22	−.18	.56
⩾66 years (44)	.04	.32	−2.43	.07	.14	.18	.42
<61 years (16)	1.58	.00	.72	.78	.74	.45	.31

^aMarkers are ordered on the basis of two-point LOD scores in all families; positions are from the Marshfield map (Broman et al. 1998; also see the Center for Medical Genetics, Marshfield Medical Research Foundation, Web site). The 16 families with mean age <61 years are a subset of the 50 early-onset families.

^bOn chromosome 11.