Table 2 Continued.
Multipoint Score |
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Two-Point Score |
Parametric |
Nonparametric |
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Model, Marker, and Age Group (No.)a | LOD | θ | LOD | HLOD | α | NPL | P |
D12S1045 (160.7 cM): | |||||||
All (94) | 1.14 | .16 | −6.14 | .01 | .05 | .48 | .31 |
<66 years (50) | 1.71 | .08 | −2.44 | .17 | .19 | .72 | .23 |
⩾66 years (44) | .00 | .50 | −3.71 | .00 | .00 | −.07 | .52 |
<61 years (16) | .51 | .04 | −.88 | .00 | .11 | .58 | .27 |
D15S652 (90.0 cM): | |||||||
All (94) | 1.04 | .16 | −1.10 | .72 | .38 | 1.23 | .11 |
<66 years (50) | .06 | .30 | −2.80 | .00 | .00 | −.23 | .58 |
⩾66 years (44) | 1.65 | .02 | 1.70 | 1.76 | .81 | 2.04 | .03 |
<61 years (16) | .27 | .12 | −.08 | .20 | .49 | .67 | .24 |
ATA34E08b (33.0 cM): | |||||||
All (94) | .38 | .24 | −3.44 | .12 | .17 | 1.30 | .10 |
<66 years (50) | .00 | .50 | −4.42 | .00 | .00 | .01 | .48 |
⩾66 years (44) | 1.58 | .04 | .98 | 1.18 | .68 | 1.89 | .03 |
<61 years (16) | .00 | .50 | −1.61 | .00 | .00 | .33 | .36 |
D2S1790 (103.2 cM): | |||||||
All (94) | .29 | .26 | −4.63 | .27 | .18 | −.01 | .49 |
<66 years (50) | .30 | .20 | −2.21 | .22 | .22 | −.18 | .56 |
⩾66 years (44) | .04 | .32 | −2.43 | .07 | .14 | .18 | .42 |
<61 years (16) | 1.58 | .00 | .72 | .78 | .74 | .45 | .31 |
Markers are ordered on the basis of two-point LOD scores in all families; positions are from the Marshfield map (Broman et al. 1998; also see the Center for Medical Genetics, Marshfield Medical Research Foundation, Web site). The 16 families with mean age <61 years are a subset of the 50 early-onset families.
On chromosome 11.