Table 2.
Segregation Analysis of EC under Model 1 (Type Influences Age At Onset )
|
Hypothesis |
|||||||
| Mendelian |
Environmental |
||||||
| Parametera | Dominant | Recessive | Codominant | No Major Type | τ’s Equal | τ’s = q | General |
| qA | .1022 | .3210 | .3210 | … | .7551 | .1481 | .7150 |
| τAA | 1.0b | 1.0b | 1.0b | … | 0c | .1481d | .5403 |
| τAB | .5b | .5b | .5b | … | 0d | .1481d | .9482 |
| τBB | 0b | 0b | 0b | … | 0d | .1481d | 0c |
| βAA | −10.4260 | −10.3268 | −10.3068 | −10.4257 | −68.6000 | −68.60 | −57.0900 |
| βAB | −10.4260d | −54.0750 | −53.8200 | −10.4257d | −10.0804 | −11.85 | −60.8300 |
| βBB | −53.0640 | −54.0750d | −55.8000 | −10.4257d | −10.6945 | −10.55 | −10.4350 |
| α | .1689 | .1665 | .1665 | .1684 | .1683 | .1753 | .1681 |
| γ | .2852 | .4981 | .4981 | .0945 | .1457 | .0975 | .6294 |
| χ2 | 24.62 | 7.95 | 7.95 | 83.53 | 63.17 | 83.46 | … |
| df | 3–4 | 3–4 | 2–3 | 5–6 | 1–2 | 2–3 | … |
| P value | <.001 | .02<P<.1 | .01<P<.05 | <.001 | <.001 | <.001 | … |
| −2lnL | 1841.19 | 1824.52 | 1824.52 | 1900.10 | 1879.74 | 1900.03 | 1816.57 |
| AIC | 1851.19 | 1834.52 | 1836.52 | 1906.10 | 1893.74 | 1912.03 | 1834.57 |
a
See Materials and Methods for definitions of the parameters.
b
Parameter is fixed at this value and is not estimated.
c
Parameter estimate went to bound.
d
Parameter is constrained to equal the preceding one and is not estimated.