TABLE 1.
Geometric mean and GMR of ertapenem AUC0-∞ for total drug in two panels of healthy men
| Panel | Dose (g) | n | Geometric mean AUC0-∞ (μg · h/ml) | Dose-adjusteda geometric mean AUC0-∞ | Dose-adjusteda AUC0-∞ GMR | 90% CI for dose-adjusteda AUC0-∞ GMR |
|---|---|---|---|---|---|---|
| A | 0.25 | 5 | 165.55 | 662.20 | 1.14 | 1.07, 1.21 |
| 1 | 6 | 581.16 | 581.16 | |||
| 2 | 6 | 1,007.90 | 503.95 | 0.87 | 0.82, 0.92 | |
| B | 0.5 | 6 | 269.08 | 807.24 | 1.13 | 1.07, 1.19 |
| 1.5 | 6 | 715.21 | 715.21 | |||
| 3 | 6 | 1,216.24 | 608.12 | 0.85 | 0.81, 0.90 |
a
Dose-adjusted to 1 g for panel A; dose-adjusted to 1.5 g for panel B.