. 2002 Nov;46(11):3506–3511. doi: 10.1128/AAC.46.11.3506-3511.2002

TABLE 2.

Geometric mean AUC_0-∞ and AUC_0-∞ GMR for total and unbound ertapenem for men and women combined (n = 16)

Pharmacokinetic parameter	Dose (g)	Geometric mean^a,^b	AUC GMR^c (90% CI)	P
AUC_0-∞ for total drug^b (μg · h/ml)	0.5	607.14	1.07 (1.02, 1.12)	0.0157
AUC_0-∞ for total drug^b (μg · h/ml)	1	568.40
	2	502.37	0.88 (0.85, 0.92)	0.0001
	3	463.76	0.82 (0.78, 0.85)	0.001
AUC_0-∞ for unbound drug^a (μg · h/ml)	0.5	31.27	0.95 (0.91, 1.00)	0.0901
AUC_0-∞ for unbound drug^a (μg · h/ml)	1	32.84
	2	37.70	1.15 (1.10, 1.20)	0.0001
	3	40.78	1.24 (1.19, 1.30)	0.0001

AUC root mean square error on the log scale is 0.080 for unbound drug. Dose adjusted to 1 g.

AUC root mean square error on the log scale is 0.074 for total drug. Dose adjusted to 1 g.

GMR relative to 1-g dose.