TABLE 4.
Mean (n = 16) pharmacokinetic parameters for unbound ertapenem in healthy volunteers receiving various single i.v. doses
| Pharmacokinetic parameter | Mean value (SD) at indicated dose
|
|||
|---|---|---|---|---|
| 0.5 g | 1 g | 2 g | 3 g | |
| AUC0-∞ (μg · h/ ml) | 15.8 (2.2) | 33.2 (5.5) | 76.6 (13.2) | 124.7 (24.6) |
| CLP (ml/min) | 538.7 (81.7) | 513.6 (80.8) | 450.5 (98.4) | 417.1 (89.3) |
| CLR (ml/min) | 243.3 (59.1)a | 223.3 (67.8)b | 194.4 (50.8) | 177.6 (53.1)b |
| CLNR (ml/min) | 294.1 (95.3)a | 289.8 (117.8)b | 256.2 (109.5) | 232.9 (93.6)b |
| VSS (liter) | 138.1 (41.9) | 123.1 (37.2) | 94.1 (33.1) | 78.5 (25.7) |
| Cmaxc (μg/ml) | 5.3 (1.2) | 12.9 (3.2) | 43.3 (14.8) | 39.4 (10.6) |
a
Based on 15 subjects; 1 subject whose urine collection during one of the intervals appeared incomplete was not included.
b
Based on 14 subjects; 2 subjects whose urine collections in one of the intervals appeared incomplete or missing were not included.
c
Cmax = concentration at end of infusion. The length of infusion was 0.5 h except for the 3-g dose, which was administered over 2 h.