Figure 1.

Pedigrees of five families with NAIC. Blackened symbols represent individuals with clinically and biochemically documented NAIC. An asterisk (*) indicates an individual whose DNA sample was genotyped. The identification prefix “N” denotes the initial 51 family members who provided DNA samples for the study; DNA samples from 7 additional NAIC patients (designated “9038,” “9039,” “9052,” “9106,” “9108,” “9133,” and “9134”) became available later and were included in the linkage and haplotype analyses. The number in a diamond-shaped symbol is the number of additional family members for whom DNA samples were not available.