Table 2.

Penalized multivariable Cox model for in-hospital mortality

	β (log-HR)	HR	95% CI	p-value (q)
Lactate	1.49	4.42	1.79–10.92	< 0.005 (0.009)
ICU day 7 sPD-L1	1.38	3.98	1.47–10.76	0.010 (0.028)
Creatinine	− 0.28	0.76	0.38–1.51	0.43 (0.61)

Values include multivariable penalized Cox proportional hazards regression analysis of arterial lactate, ICU day 7 plasma sPD-L1, and plasma creatinine levels

Data shown are the regression coefficients β (log-HRs), corresponding HRs, 95% CIs, and two-sided p-values (Wald tests); q-values are p-values adjusted for multiple testing (false discovery rate)

For continuous predictors, HRs represent the relative change in hazard per 1-unit increase in the predictor

CI: confidence interval; HR: hazard ratio; sPD-L1, soluble programmed death-ligand 1