FIG. 1.
Pharmacokinetics of the active STAMP metabolite ala-d4T-MP in STAMP-treated mice. Shown are the chemical structures of STAMP and ala-d4T-MP (A) and ala-d4T-MP levels in plasma as a function of time after i.v. administration (B), i.p. administration (C), and p.o. gavage administration (D) of a 100-mg/kg bolus dose of STAMP. Data points are the means + SEMs (error bars) for the levels in plasma for each time point (four BALB/c mice and four CD-1 mice [five in panel B]). The pharmacokinetic parameters estimated from individual experiments are given in the insets with means ± SEMs. tmax, time to Cmax