Figure 1 .

Partial pedigree of the extended kindred. The five culture-negative cases (individuals 10, 13, 15, 21, and 22) had radiological abnormalities consistent with active tuberculosis; individuals 10 and 15 also had symptoms associated with tuberculosis. Not included in the pedigree are nine individuals from whom DNA was not available and among whom there were two infants classified as culture-negative cases (both had radiological abnormalities), three children classified as not having disease (all PPD negative; two were culture negative, and no culture was taken from the third), and four people with unknown disease phenotype. The order of the information below each circle is as follows: mycobacterial test result (c+ = M. tuberculosis culture positive; c− = M. tuberculosis culture negative; nd = no data), liability class, NRAMP1 haplotype, D2S424 alleles, and TNF haplotype. D2S424 alleles 1, 2, and 3 are 185, 181, and 157 bp, respectively. BCG indicates that the individual was vaccinated. For classification of disease phenotype and definition of liability classes, see the Subjects and Methods section; for NRAMP1 andTNF haplotypes, see tables 2 and 3, respectively.