Abstract
Background
Indigenous communities in northern Manitoba face a high burden of musculoskeletal (MSK) conditions and limited access to care. In October 2023, a new chiropractic service was launched in Cross Lake, Manitoba, aiming to improve MSK care access. This study explored: (1) the nature of MSK-related care provided at the Cross Lake Nursing Station, and (2) changes in clinical management during the first 10 months post-implementation.
Methods
We conducted a retrospective chart review (standardized 14-item form) for two periods: December 2021–2022 (pre-implementation) and October 2023–August 2024 (post-implementation). Data on presentations, imaging, treatments, and referrals were analyzed descriptively.
Results
Post-implementation, imaging use declined (63.4% to 44.9%), as did prescription of NSAIDs (80.5% to 53.1%), acetaminophen (63.4% to 32.7%), and opioids (21.9% to 8.2%). Muscle relaxant prescriptions increased, while pregabalin/gabapentin remained stable.
Conclusion
The new chiropractic service may be associated with reduced use of imaging and common medications for MSK conditions.
Keywords: musculoskeletal, spine care, retrospective chart review, medically underserved area, chiropractic, non-pharmacological, Indigenous, opioid
Abstract
Les soins médicaux de routine pour les adultes atteints de troubles musculo-squelettiques dans la communauté autochtone de Pimicikamak, dans le nord du Manitoba, avant et après la mise en oeuvre du modèle du Global Spine Care Initiative model: un examen rétrospectif des dossiers avec une période d’observation de 10 mois après la mise en oeuvre. Un projet de recherche collaboratif entre World Spine Care Canada (WSCC), Pimicikamack Okimawin et la Station de soins infirmiers de Cross Lake
Contexte
Les communautés autochtones du nord du Manitoba font face à un fardeau élevé de conditions musculo-squelettiques (MSK) et à un accès limité aux soins. En octobre 2023, un nouveau service de chiropratique a été lancé à Cross Lake, au Manitoba, visant à améliorer l’accès aux soins musculosquelettiques. Cette étude a exploré : (1) la nature des soins liés aux conditions MSK fournis à la station de soins infirmiers de Cross Lake, et (2) les changements dans la gestion clinique au cours des 10 premiers mois suivant la mise en oeuvre.
Méthodes
Nous avons réalisé un examen rétrospectif des dossiers (formulaire standardisé de 14 éléments) pour deux périodes : Décembre 2021–2022 (avant la mise en oeuvre) et octobre 2023–août 2024 (après la mise en oeuvre). Les données sur les présentations, l’imagerie, les traitements et les références ont été analysées de manière descriptive.
Résultats
Après la mise en oeuvre, l’utilisation d’imageries a diminué (de 63,4 % à 44,9 %), tout comme la prescription d’anti-inflammatoires non stéroïdiens (de 80,5 % à 53,1 %), d’acétaminophène (de 63,4 % à 32,7 %) et d’opioïdes (de 21,9 % à 8,2 %). Les prescriptions de relaxants musculaires ont augmenté, tandis que celles du pregabalin/gabapentin sont restées stables.
Conclusion
Le nouveau service de chiropratique pourrait être associé à une réduction de l’utilisation d’imageries et de médicaments courants pour les conditions musculo-squelettiques.
MOTSCLÉS: musculosquelettique, soins de la colonne vertébrale, examen rétrospectif des dossiers, zone médicalement mal desservie, chiropratique, non pharmacologique, autochtone, opioïde
Introduction
Musculoskeletal (MSK) disorders, including back and neck pain, affect over 1.7 billion people globally and have been the leading cause of disability since 1990.1 Spine-related disorders disproportionately impact disadvantaged populations, including individuals living in poverty, rural communities, women, and older adults.2 Without access to appropriate care, these conditions can lead to reduced mobility and poor overall health, with cascading effects including social isolation, diminished work capacity, and poverty.
Spine complaints are among the most common reasons for people to seek care from their primary care clinicians and account for nearly half of all opioid prescriptions.1–5 Central to the problem is the prevalent use of low-value care-interventions with minimal or no evidence for benefits relative to their potential harm, costs, or healthcare burden.6 For example, patients with acute low back pain (LBP) who receive diagnostic imaging, opioid prescriptions, and specialist referrals within 6 weeks of the initial visit are more than twice as likely to develop chronic pain than those receiving no such care.7,8 Similarly, prescribing opioids for non-specific LBP is linked to prolonged work disability, increased medical costs, and higher surgical rate.7,8
Systemic and contextual factors contribute to the over-use of low-value spine care, including limited access to non-pharmacologic alternatives, financial barriers, patient expectations, practitioner beliefs, and healthcare systems oriented toward a biomedical care approach.9–11 In contrast, international clinical guidelines for non-specific LBP recommend emphasizing patient education, staying active, advice on self-care, and home and/or group exercise as first-line treatment.12 While discouraging passive modalities, the guidelines do recommend therapies like massage, acupuncture, and manual therapy, with a short course of non-steroidal anti-inflammatory drugs (NSAIDs) as secondary care options. Routine use of acetaminophen (paracetamol), skeletal muscle relaxants, antidepressants, anticonvulsants/antiepileptics, opioids and spinal injections for non-specific spine pain are discouraged. Multidisciplinary treatment and psychological therapy may be considered for specific subgroups at risk of delayed recovery.12–21 Despite the evidence, the uptake of these guidelines in primary care remains suboptimal. 22,23
World Spine Care (WSC) is a group of four organizations incorporated as not-for-profit charities in their relevant jurisdictions dedicated to bridging the gap in evidence-based treatment for spinal conditions in underserved regions (https://www.worldspinecare.org/). Their mission is to improve the lives, functionality, and participation of individuals living in these communities.24 To advance this mission, WSC established the Global Spine Care Initiative (GSCI), a multiphase project to develop and implement an evidence-based, culturally adapted, and sustainable model of care (MoC) for spine-related conditions.25,26 The GSCI MoC incorporates triage tools and care pathways tailored to low-resource settings with limited or no access to spine care.27,28
While the GSCI MoC has been applied in WSC clinics in various international settings, the current study marks the first implementation study in a remote Canadian Indigenous community.29 In partnership with Pimicikamak Okimawin leadership, WSC Canada introduced a chiropractic service in Cross Lake, Manitoba in 2023. Cross Lake is located approximately 800 km north of Winnipeg (https://crosslakeband.ca/), with a population of 6,734 on the treaty and 2,715 on the non-treaty land and includes First Nations, Métis and non-Indigenous people.30 Cree and English are spoken in this community.31 Prior to this initiative, limited evidence-based, primary-level spine care was available locally.
Context
Indigenous communities in northern Manitoba experience a disproportionately high burden of injuries, acute illness, and chronic disease, in addition to the legacy of colonization and systemic inequities.32–34 Communities like Cross Lake First Nation face unique barriers to care, including geographic isolation, limited local health infrastructure, and dependence on fly-in nurses, nurse practitioners and medical doctors (MDs) to deliver care at the Cross Lake Nursing Station, some of whom may be unfamiliar with the cultural context and long-term patient needs.35,36 Specialized spine care is only available in distant urban centres such as The Pas (401 km away), Thompson (255 km away), or Winnipeg (770 km away). Travel to these distant centres is not patient-centric, logistically difficult, financially burdensome, and often not fully covered by the provincial health system.
To address this critical gap and remove geographic and financial barriers to evidence-based spine care, WSC Canada introduced a community-based spine care service, co-designed with Pimicikamak leadership to ensure the delivery of culturally relevant care within the existing healthcare system.29 The service, launched on October 5, 2023, is delivered at the Cross Lake Nursing Station by licensed chiropractors up to three days per week. The proximity to other medical services allows for close interaction with other health care providers. The service is free of charge and can be accessed directly, or through referral from various professionals, namely MDs (northern family medicine physicians and emergency physicians), nurses, and mental health counsellors at the Cross Lake Nursing Station. In July 2023, the WSC clinicians provided formal education to MDs and nursing staff on the application of the GSCI triage and care pathways.27,28 They also engaged in informal discussions regarding current recommendations from up to date international evidence-based guidelines on the management of spinal pain as outlined by the GSCI21,37,38 and the World Health Organization12.
The overarching goal of this study was to evaluate the potential clinical impact of integrating the GSCI MoC in the community in collaboration with local guidance and feedback.29,39,40 The current study aimed: 1) to describe the nature of routine MSK care delivered to adults by northern family medicine physicians, nurses and nurse practitioners at the Cross Lake Nursing Station over the previous year, and 2) to compare diagnostic imaging use and patient management – including pharmaceutical, non-pharmaceutical treatments, and referrals—before and after the implementation of the new chiropractic service.
Methods
Ethics and Agreements
A research agreement (Pimicikamak Okimawin leadership, World Spine Care, University of Manitoba and Université du Québec à Trois-Rivières) was signed on July 7, 2022, and a data transfer agreement (The Global Spine Care Initiative, Health and Welfare Canada Cross Lake Nursing Station) was signed on August 22, 2022. Ethical approval was obtained from the University of Manitoba’s Research Ethics Board (#HE2022-0249).
Design and population
We conducted a retrospective pilot medical chart review of a sample of adults (≥18 years) who presented to the Cross Lake Nursing Station with a primary complaint of musculoskeletal (MSK) pain. A sample size calculation determined that 68 participants were needed for a population of 9,400, with a 90% confidence interval and a 10% margin of error for this exploratory study; given operational constraints, we proceeded with a convenience sample appropriate to this exploratory study.
Data collection procedures
A standardized 14-item data extraction form was developed (Appendix 1), adapted from the GSCI’s spine care pathway and clinical flashcards27,28 used in previous WSC-affiliated clinic. The form was used to collect information on patients’ demographics (age, gender), clinical presentation (pain location: lumbar, thoracic, cervical, extremity; duration: acute, chronic; intensity: 0–10 scale; onset: traumatic, gradual), history (first and second episodes of MSK pain; visits related to back and neck pain; function limitations: work, activities of daily living), and care provided (use of diagnostic imaging: radiographs, advanced imaging; prescribed and non-prescribed medication: NSAIDs, non-opioid, other, and opioid medication; non-pharmacological care: physiotherapy, massage, other; patient referrals). The items were reviewed and refined based on team feedback and piloted on the first 10 charts before full implementation, and data incorporated after these were re-reviewed.
Participants were identified through two recruitment methods: 1) Adults with complaints of spinal symptoms or extremity pain who called the Cross Lake Nursing Station for an appointment or were seen by MDs and/or nurses either in the Nursing Station medical clinic or emergency department, were informed of the study and asked for permission to be contacted; and 2) a community Facebook notice inviting eligible individuals to contact the research team. The service was co-designed with Pimicikamak leadership to enhance cultural relevance.
All participants voluntarily provided informed consent, allowing access to their medical records. Two local research assistants retrieved paper-based records for both emergency and scheduled visits. Data extraction was completed by two licensed chiropractors in December 2022 (pre-implementation: December 2021–December 2022) and in August 2024 (post-implementation: October 2023–August 2024). All data were de-identified by the data extractors and entered into a secure digital platform designed for the study (using JavaScript Object Notation (JSON)) or into an Excel file, with automatic backup to the University of Manitoba’s secure server.
Analysis
Descriptive analyses were conducted using SAS v9.4 (Copyright © 2012–2018, SAS Institute Inc., Cary, NC, USA. SAS and all other SAS Institute Inc. product or service names are registered trademarks or trademarks of SAS Institute Inc., Cary, NC, USA). Numerical variables were summarized using means and standard deviations, while categorical variables were reported as percentages of the sample endorsing each category. Paired comparison of patients with charts included at both time points was also conducted. Given the exploratory design, convenience sampling, and documentation variability, statistical analysis was limited to descriptive statistics (means, standard deviations, frequencies and percentages) and no inferential hypothesis testing was performed.
Results
Patient Characteristics
Of the 107 patient charts reviewed, 41 were included in the pre-implementation period (mean age=50.9 years, 60.9% self-identified as female), and 49 charts in the post-implementation periods (49.5 years, 67.4% female) (Table 1). The 17 remaining charts were excluded as they did not meet the eligibility criteria (i.e., adults with a primary MSK complaint).
Table 1.
Patient characteristics, presenting complaints, diagnostic imaging, and management.
| Pre-Implementation (n=41) n (%) unless otherwise indicated |
Post-implementation (n=49) n (%) unless otherwise indicated |
Included in both pre- and post-implementation periods (n=21) | ||
|---|---|---|---|---|
| Pre-implementation n (%) unless otherwise indicated |
Post-implementation n (%) unless otherwise indicated |
|||
| Gender | ||||
| Female | 25 (60.9%) | 33 (67.4%) | 16 (76.2%) | |
| Male | 16 (39.1%) | 16 (32.6%) | 5 (23.8%) | |
| Age (years) | 50.9 (SD=11.2) | 49.5 (SD=12.1) | 50.7 (SD=12.0) | |
| Range | 18–70 | 19–71 | 18–70 | |
| Onset | ||||
| Non-traumatic | 36 (87.8%) | 38 (77.6%) | 19 (90.5%) | 18 (85.7%) |
| Traumatic | 5 (12.2%) | 11 (22.5%) | 2 ( 9.5%) | 3 (14.3%) |
| Pain location | ||||
| • Lumbar | 26 (63.4%) | 27 (59.2%) | 13 (61.9%) | 11 (52.4%) |
| • Thoracic | 4 ( 9.8%) | 2 ( 4.1%) | 2 ( 9.5%) | 1 ( 4.8%) |
| • Cervical | 3 ( 7.3%) | 5 (10.2%) | 2 ( 9.5%) | 2 ( 9.5%) |
| • Extremities | 8 (19.5%) | 11 (22.5%) | 4 (19.1%) | 6 (28.6%) |
| • Other | 0 ( 0.0%) | 2 ( 4.1%) | - | 1 ( 4.8%) |
| Pain intensity | ||||
| Not reported | 32 (78.1%) | 41 (83.7%) | 16 (76.2%) | 16 (76.2%) |
| Pain duration | ||||
| • Acute (< 3 months) | 26 (63.4%) | 24 (49.0%) | 13 (61.9%) | 8 (38.1%) |
| • Chronic (> 3 months) | 15 (19.5%) | 20 (40.8%) | 8 (38.1%) | 11 (52.4%) |
| • Not reported | 0 ( 0.0%) | 5 (10.2%) | - | 2 ( 9.5%) |
| Able to work/ Perform ADLs | ||||
| • Yes | 24(58.5%) | 42 (85.7) | 11 (52.3%) | 18 (85.7%) |
| • No | 17 (41.5%) | 7 (14.3%) | 10 (47.6%) | 3 (14.3%) |
| Number of episodes of care for an MSK complaint | ||||
| 1 | 32 (78.1%) | 40 (81.6%) | 15 (71.4%) | 15 (71.4%) |
| 2 | 9 (21.9%) | 6 (12.2%) | 6 (28.6%) | 4 (19.1%) |
| 3 | - | 3 ( 6.1%) | - | 2 ( 9.5%) |
| Number of Visits across episodes | ||||
| Range (n) | 1 to 24 | 1 to 24 | 1 to 24 | 1 to 5 |
| 1 | 17 (41.5%) | 28 (57.1%) | 8 (38.1%) | 8 (38.1%) |
| 2 | 7 (17.1%) | 11 (22.5%) | 3 (14.2%) | 7 (33.3%) |
| 3 | 8 (19.5%) | 5 (10.2%) | 2 ( 9.5%) | 2 ( 9.5%) |
| 4 | 3 ( 7.3%) | 3 ( 6.1%) | 3 (14.3%) | 3 (14.3%) |
| 5 | 1 ( 2.4%) | 1 ( 2.0%) | - | 1 ( 4.8%) |
| >5 | 5 (12.2%) | 1 ( 2.0%) | 5 (23.8%) | - |
| Any Imaging | ||||
| • Number of patients | 26 (63.4%) | 22 (44.9%) | 13 (61.9%) | 10 (47.6%) |
| • Number of imaging referrals | 33 | 23 | 17 | 13 |
| • Plain film x-rays | 20 (48.8%) | 12 (14.3%) | 9 (42.9%) | 6 (28.6%) |
| • CT scan | 5 (12.2%) | 4 (8.2%) | 3 (14.3%) | 1 ( 4.8%) |
| • MRI | 8 (19.5%) | 7 (14.3%) | 5 (23.8%) | 3 (14.3%) |
| OTHER | 3 (14.3%) | |||
| Imaging location | 33 imaging referrals | 23 imaging referrals | 17 imaging referrals | 13 imaging referrals |
| • Local (Cross Lake) | 16 (48.5%) | 7 (30.4%) | 6 (35.3%) | 4 (30.8%) |
| • Remote (Winnipeg, Thomson, Norway House, Winkler) | 16 (48.5%) | 11 (47.8%) | 10 (58.8%) | 8 (61.5%) |
| • Not reported | 1 (3.0%) | 5 (21.7%) | 1 ( 5.9%) | 1 ( 7.8%) |
| Non-pharmacological Care | 25 (61.0%) | 10 (20.4%) | 10 (58.8%) | 9 (42.9%) |
| • Patient education, Advice on self-care, applying heat or ice | 19 (46.3%) | 5 (10.2%) | 8 (38.1%) | 1 (4.8%) |
| • Exercise | 6 (14.6%) | 2 ( 4.1%) | 4 (19.0%) | 1 (4.8%) |
| • Massage therapy | 1 (2.4%) | 3 (6.1%) | 1 (4.8%) | 1 (4.8%) |
| • Assisted device | 6 (14.6%) | 2 (4.1%) | 3 (14.3%) | 1 (4.8%) |
| • Chiropractic Care | ----------- | 6 (12.2%) | ------------ | 5 (23.8%) |
| Pharmacological care | 31 (75.6%) | 30 (61.2%) | 17 (81.0%) | 14 (66.7%) |
| • Prescription NSAIDs | 28 (68.3%) | 15 (30.6%) | 16 (76.2%) | 6 (28.6%) |
| • Non-Prescription (recommended) NSAIDS | 5 (12.2%) | 11 (22.5%) | 1 (4.8%) | 3 (14.3%) |
| NSAIDS (combined prescribed and non-prescribed) | 33 (80.5%) | 26 (53.1%) | 16 (76.2%) | 8 (38.1%) |
| • Acetaminophen | 26 (63.4%) | 16 (32.7%) | 12 (57.1%) | 6 (28.6%) |
| • Muscle relaxants | 3 (7.3%) | 7 (14.3%) | 2 (9.5%) | 3 (14.3%) |
| • Opioids / Narcotics | 9 (21.9%) | 4 (8.2%) | 6 (28.6%) | 2 (9.5%) |
| • Pregabalin or Gabapentin | 5 (12.2%) | 6 (12.2%) | 3 (14.3%) | 4 (19.1%) |
| • Other (includes sedatives, antidepressants, anti-anxiety, Voltaren gel, capsaicin cream, antibiotics, anti-rheumatics etc.) | 13 (31.7%) | 11 (22.5%) | 5 (23.8%) | 6 (28.6%) |
| Referrals to an outside distant facility | 11 (26.8%) | 11 (22.4%) | 8 (38.1%) | 6 (28.6%) |
| • Physiotherapy | 7 (12.5%) | 2 (4.1%) | 4 (19.1%) | 0 (0.0%) |
| • Medical specialists (orthopedic, rheumatology, neurosurgery) | 9 (21.9%) | 9 (18.4%) | 7 (33.4%) | 6 (28.6%) |
Number of imaging referrals can exceed the number of patients imaged because a patient may receive multiple modalities. (Paired pre = 9+3+5 = 17; paired post = 6+1+3 + other 3 = 13).
ADLs = activities of daily living;
PROMs = patient-reported outcome measures;
PREMs = patient-reported experience measures.
The proportion of cases with a traumatic onset increased from 12.2% to 22.5% during the post-implementation period. Low back pain remained the most common complaint across both periods (63.4% pre- vs 59.2% post-), while cases involving neck pain (7.3% to 10.2%) and extremity pain (19.5% to 22.5%) both showed a slight increase. The proportion of patients with chronic pain (duration >3 months) more than doubled, from 19.5% to 40.8%. Pain intensity was reported in approximately 20% of charts in both periods. Most patients presented with a single episode of MSK care (78.1% pre- vs. 81.6% post-) and were seen less than three times by medical staff (MDs or nurses) in both time periods. Interestingly, fewer second episodes of MSK care were noted post-implementation (21.9% vs. 12.2%).
Imaging Utilization
Overall, imaging rate declined from 63.4% to 44.9% post-implementation. This included a reduction in plain film radiography (48.8% to 14.3%), CT scans (12.2% to 8.2%), and MRIs (19.5% to. 14.3%).
Patient Management
Non-Pharmacological Care
Recommendations (from MDs and nurses) for non-pharmacological interventions declined post-implementation, notably for patient education and self-care advice (43.3% to 10.2%), exercise prescriptions (14.6% to 4.1%). Recommendations for manual therapy remained low in both periods.
Pharmacological Care
There was a notable reduction in prescribed NSAIDs (68.3% to 30.6%, although the overall use of NSAIDs showed a lesser decrease from 80.5% to 53.1% when taking over-the-counter NSAIDs into account), acetaminophen (63.4% to 32.7%), and opioids (21.9% to 8.2%). Other medications (e.g., sedatives, antidepressants, anti-anxiety, Voltaren gel, and capsaicin cream) also decreased (31.7% to 22.5%). Conversely, prescriptions for muscle relaxants (7.3% to 14.3%) increased, while prescriptions for Pregabalin or Gabapentin remained unchanged (12.2%).
Referrals
Referrals to external distant facilities decreased from 26.8% to 22.4%. This included medical specialist referrals (21.9% to 18.4%), and physiotherapy referrals (12.5% to 4.1%). Additionally, six new referrals (12.2%) to the onsite WSCC (World Spine Care Canada) chiropractic clinic occurred in the post-implementation period.
Paired comparison of patients with charts included at both time points
Twenty-one patient charts (mean age 50.7 years, 76.2% females) were included in the pre- and post-implementation periods. (Table 1) Among these, the proportion of patients with a chronic complaint increased (38.1% to 52.4%), suggesting conditions transitioned from acute to chronic pain for some patients. Lumbar pain remained the most frequent complaint but declined slightly (61.9% to 52.4%), suggesting either symptom resolution or a change in complaint priority. Extremity complaints increased in the post-implementation period (19.1% to 28.6%), while the proportion of neck and thoracic complaints remained stable. Most patients had only one episode of care across periods (71.4%).
Imaging Utilization
Among patients seen at both time points, imaging ordering (plain film, CT, MRI) decreased in the post-implementation period (61.9% to 47.6%).
Non-Pharmacological Care
Interestingly, fewer patients received patient education and self-care advice (38.1% to 4.8%) or exercise prescriptions (19% vs. 4.8%) from MDs, nurses and nurse practitioners. Referrals for massage remained unchanged (4.8%), while a few referrals (23.8%) were made to the onsite chiropractic clinic.
Pharmacological Care
A decline in the overall prescription of NSAIDS (81% to 38.1%), opioids (28.6% to 9.5%), and acetaminophen (57.1% to 28.6%) was noted post-implementation.
Discussion
In this exploratory retrospective pre–post chart review, after introducing an onsite GSCI-aligned chiropractic service, we observed lower imaging and reduced prescribing of NSAIDs, acetaminophen, and opioids. These associative changes align with prior reports of more guideline-concordant care when non-pharmacological options are integrated into primary care teams.41–43
Consistent with broader spine care populations,44 most patients presenting to the Cross Lake Nursing Station identified as female, in their early 50s, reporting non-traumatic low back or neck pain. Across both time periods, most individuals sought care for a single episode and were seen fewer than three times by medical staff, suggesting that MSK complaints were generally managed within a short care window.
Imaging ordered by medical staff declined post-implementation, though rates remained a high considering serious pathology (e.g., cancer, infection) or specific pathology (e.g., spinal canal stenosis, compression fracture)37, 45, 46 are estimated to be the causes of spinal pain in less than 1% and 10% in the primary care setting, respectively. 47,48,49 While trauma and extremity presentations were relatively more frequent post-implementation, not all such cases warrant imaging; the reduction may reflect increased comfort with non-pharmacological care pathways. Because red-flag documentation was unavailable, appropriateness could not be assessed and should be a focus of future quality improvement study.
While reductions in NSAIDs, acetaminophen, and opioids are consistent with greater availability of non-pharmacological care and staff education41,42,43, the increased use of muscle relaxants in the post-implementation period warrants monitoring given mixed evidence50,51. Notably, gabapentinoid prescriptions remained unchanged, despite limited benefit for back pain with or without sciatica52–55, and increasing concerns of misuse56. We avoid causal inference with these data but note these as pragmatic practice signals. Due to limitations in the available data, co-prescription of opioids and gabapentinoids could not be determined, and suggests an important gap given the increased risk of opioid-related mortality associated with such combinations.57 Across Manitoba, rising overdose deaths from opioids58,59 highlights the need for a more holistic approach to pain management specific to substance use interventions and as a public health priority60. Despite the evidence against opioid prescription as a first-line treatment for acute or chronic spine pain61–63, and the ongoing opioid crisis across North America64, pharmacological options are often more readily accessible than non-pharmacological alternatives, leading to their continued use65.
Non-pharmacological care and role transition
Charted MDs/nurse delivery of education/exercise declined, possibly reflecting task re-distribution to the on-site chiropractic service. An unpublished report prepared for our funders (Oct 2023–May 2025) describes chiropractic care provided to 232 unique patients at Cross Lake Nursing Station during the post-implementation period (October 2023-May 2025), totaling 1384 patient visits.66 The report documents high rates of education/exercise within chiropractic encounters, suggesting complementary roles, with approximately 80% of patients receiving education and rehabilitation/ exercise interventions, a proportion much higher than observed nationally and internationally. 67,68 However, the implementation window of the project extends beyond our study period (our Results include six WSCC referrals Oct 2023–Aug 2024). Together, our findings39,40 support growing recommendations to integrate non-pharmacological care into interdisciplinary teams for a full range of evidence based spinal pain interventions rather than an add-on service to improve patient outcomes.12–14 Consistent, harmonized documentation would support interprofessional communication, improve visibility of non-pharmacological care across providers, ensuring continuity and consistency of care.
Referrals to external services including physiotherapy and specialist care also slightly declined post-implementation. This trend may be attributed to the increased access to the newly introduced chiropractic service, which received a modest number of new referrals during the study period. Notably, several referrals were still pending at the time of data abstraction, suggesting that the full impact of the service may not yet be captured. The unpublished report indicates that nearly one fifth (18.2%) of the 232 unique patients had been referred to the WSC Canada clinic by either Cross Lake Nursing Station MDs (7.3%), a registered nurse (7.7%) or the staff (3.2%).66
Equity and Culture
Despite the documented changes in care processes, few patient charts included patient-reported outcome or experience measures (PROMs/PREMs).69 While these tools can help monitor MSK care quality,70–72 they are often grounded in Western biomedical frameworks that may fail to capture Indigenous perspectives of health, including physical, emotional, and spiritual healing and community well-being32. In particular, emotional and spiritual dimensions of pain, often rooted in the intergenerational experience of colonization and the ongoing experiences of systemic racism, can profoundly affect the healthcare experiences of Indigenous persons in Canada and requires culturally responsive approaches to assessment and care.73,74
Systemic inequities in the Canadian healthcare system— including racism, implicit bias, and harmful stereotypes contribute to the disproportionate burden of chronic MSK conditions among Indigenous populations.75–79 These inequities are exacerbated by limited access to primary and specialized pain services in remote communities, as well as financial barriers and as a result, there is often over-reliance on pharmaceuticals, including opioids, as first-line treatment.78,79
Expanding access to culturally safe, non-pharmacological therapies requires integrating Indigenous healing practices such as land-based healing, traditional medicine, and the active involvement of Elders and Knowledge Keepers into care pathways.76 Other holistic approaches, such as chiropractic care, also merit consideration as a first-line intervention. Holistic practices are not peripheral but central to Indigenous worldviews on health and should be embedded within primary care systems.80,81
Culturally safe care involves respectful engagement that recognizes and strives to address power imbalances inherent in the healthcare system.81 For Indigenous peoples, this means comprehensive care models that incorporates family, community traditions, ceremonies (e.g., smudging, sweats, talking circles), and protocols which are all elements central to healing.82–84 Integrating traditional healing practices with multidisciplinary models for managing chronic pain may improve outcomes by aligning care with cultural values and lived experiences of patients.75 Importantly, traditional medicine and conventional treatments need not be mutually exclusive, as their integration can support more holistic, person-centered care.76,81,85
To ensure that culturally responsive care is consistently delivered, there is a need to co-develop culturally safe care standards with Elders, traditional healers, and community members.85 Such standards should inform provider licensing, education, and ongoing evaluation in primary care fields, including chiropractic.86
In parallel, investments in training and certifying local Indigenous health workers, including nurse practitioners, physician assistants, and providers of manual therapy and mental health therapies, can strengthen cultural competence and foster trust.87,88 These individuals often share languages, values, and community ties, and are more likely to remain in their roles over time.
Finally, reducing reliance on short-term fly-in health providers is essential for improving relational continuity and cultural safety. Increasing the number of full-time community-based medical and allied health professionals such as chiropractors, can help establish sustainable, community-embedded care.89–91
Strengths and limitations
Few studies have documented routine MSK care delivery in remote Indigenous communities in Canada. The present study offers valuable preliminary insights into how the introduction of a culturally responsive spine care model may influence clinical practices in underserved Indigenous communities. However, several limitations must be acknowledged including convenience sampling from paper charts; potential selection/measurement bias (including inconsistent pain chronicity and red-flag capture); short post window (10 months); 43% overlap of patients across periods; small sample precluding inferential testing. Findings are preliminary and hypothesis-generating. Finally, the sparse and variable quality of clinical documentation restricted our ability to assess the appropriateness of care, such as whether imaging was warranted based on red flags, or higher-risk medications (e.g., opioids and gabapentinoids) were prescribed concurrently.56
Implications for practice and future research
This study contributes to the limited body of literature describing routine MSK care in northern Indigenous communities and provides preliminary evidence that integrating the GSCI model may influence clinical practice patterns towards evidence-based guideline congruent care. Customizing this model to align with the cultural, spiritual, and social contexts of the local community is essential for sustainability and community acceptance.29 Future research should aim to incorporate longitudinal and mixed-methods designs to better understand outcomes over time, include culturally relevant PROMs/PREMs to capture patients’ lived experiences, and partner with communities in co-designing services that reflect their values and preferences.92 Quasi-experimental or implementation studies could further evaluate the impact of the GSCI model on care quality, safety, and patient outcomes in underserved settings.
Conclusion
This exploratory study suggests that implementing a culturally sensitive chiropractic service based on the GSCI model was associated with reduced imaging and lower prescribing of several common MSK medications in a remote Indigenous community. Larger, longitudinal, mixed-methods evaluations with standardized documentation and culturally relevant PROMs/PREMs are warranted.
Acknowledgments
We thank our community partners for their guidance and their efforts to ensure that the data collection tool and study results reflect the lived experiences of the people of Pimicikamak. We also thank the nursing station staff (administrative, security and medical records) for providing lodging and support, the medical staff for their cooperation and collaboration, and the Cross Lake Band for their ongoing support and hospitality.
Abbreviations
- GSCI
Global Spine care Initiative
- LBP
Low Back Pain
- NSAIDs
non-steroidal anti-inflammatory drugs
- PREM
Patients Reported Experience Measures
- PROMs
Patient Reported Outcome Measures
- WSC
World Spine Care
- WSCC
World Spine Care Canada
Appendix 1
Chart review: pre- and post-implementation data collection tool
Footnotes
Conflicts of Interest and Funding: The authors have no disclaimers or competing interests to report in the preparation of this manuscript. This work was supported by Health Canada Substance Use and Addictions Program (agreement # 2223 HQ 000126), The Canadian Chiropractic Research Foundation (CCRF), The Canadian Chiropractic Association (CCA), Healthcare Excellence Canada, and The Skoll Foundation.
References
- 1.Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10267):2006–2017. doi: 10.1016/S0140-6736(20)32340-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Ferreira ML, De Luca K, Haile LM, Steinmetz JD, Culbreth GT, Cross M, et al. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(6):e316–329. doi: 10.1016/S2665-9913(23)00098-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. MMWR Recomm Rep. 2022;71(3):1–95. doi: 10.15585/mmwr.rr7103a1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Finley CR, Chan DS, Garrison S, Korownyk C, Kolber MR, Campbell S, et al. What are the most common conditions in primary care? Systematic review. Can Fam Physician Med Fam Can. 2018;64(11):832–840. [PMC free article] [PubMed] [Google Scholar]
- 5.Wu V, Goto K, Carek S, Petrizzi M, Deck JW, Sulapas I, et al. Family Medicine Musculoskeletal Medicine Education: A CERA Study. Fam Med. 2022;54(5):369–375. doi: 10.22454/FamMed.2022.975755. [DOI] [PubMed] [Google Scholar]
- 6.Schwartz AL, Landon BE, Elshaug AG, Chernew ME, McWilliams JM. Measuring Low-Value Care in Medicare. JAMA Intern Med. 2014;174(7):1067. doi: 10.1001/jamainternmed.2014.1541. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Deyo RA, Von Korff M, Duhrkoop D. Opioids for low back pain. BMJ. 2015;350(jan05 10):g6380–g6380. doi: 10.1136/bmj.g6380. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Franklin GM, Stover BD, Turner JA, Fulton-Kehoe D, Wickizer TM. Early Opioid Prescription and Subsequent Disability Among Workers With Back Injuries: The Disability Risk Identification Study Cohort. Spine. 2008;33(2):199–204. doi: 10.1097/BRS.0b013e318160455c. [DOI] [PubMed] [Google Scholar]
- 9.Hartvigsen J, Kamper SJ, French SD. Low-value care in musculoskeletal health care: Is there a way forward? Pain Pract. 2022;22(S2):65–70. doi: 10.1111/papr.13142. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Ingvarsson S, Augustsson H, Hasson H, Nilsen P, Von Thiele Schwarz U, Von Knorring M. Why do they do it? A grounded theory study of the use of low-value care among primary health care physicians. Implement Sci. 2020;15(1):93. doi: 10.1186/s13012-020-01052-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Lantz PM, Goldberg DS, Gollust SE. The Perils of Medicalization for Population Health and Health Equity. Milbank Q. 2023;101(S1):61–82. doi: 10.1111/1468-0009.12619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.World Health Organization. WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings. www.who.int. 2023. 2023. Available from: https://www.who.int/publications/i/item/9789240081789. [PubMed]
- 13.Lin I, Wiles L, Waller R, Goucke R, Nagree Y, Gibberd M, et al. What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical practice guidelines: systematic review. Br J Sports Med. 2020;54(2):79–86. doi: 10.1136/bjsports-2018-099878. [DOI] [PubMed] [Google Scholar]
- 14.Foster NE, Anema JR, Cherkin D, Chou R, Cohen SP, Gross DP, et al. Prevention and treatment of low back pain: evidence, challenges, and promising directions. The Lancet. 2018;391(10137):2368–2383. doi: 10.1016/S0140-6736(18)30489-6. [DOI] [PubMed] [Google Scholar]
- 15.Corp N, Mansell G, Stynes S, Wynne-Jones G, Morsø L, Hill JC, et al. Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines. Eur J Pain. 2021;25(2):275–295. doi: 10.1002/ejp.1679. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Wong JJ, Côté P, Sutton DA, Randhawa K, Yu H, Varatharajan S, et al. Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur J Pain. 2017;21(2):201–216. doi: 10.1002/ejp.931. [DOI] [PubMed] [Google Scholar]
- 17.Parikh P, Santaguida P, Macdermid J, Gross A, Eshtiaghi A. Comparison of CPG’s for the diagnosis, prognosis and management of non-specific neck pain: a systematic review. BMC Musculoskelet Disord. 2019;20(1):81. doi: 10.1186/s12891-019-2441-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Kantner S, Ferguson AJR. Noninvasive nonpharmacological treatment for chronic pain: a systematic review update. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020. Apr, Report No.: 20-EHC009. [PubMed] [Google Scholar]
- 19.Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, et al. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update. Rockville (MD): Agency for Healthcare Research and Quality (US); 2020. (AHRQ Comparative Effectiveness Reviews) [PubMed] [Google Scholar]
- 20.Oliveira CB, Maher CG, Pinto RZ, Traeger AC, Lin CWC, Chenot JF, et al. Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview. Eur Spine J. 2018;27(11):2791–2803. doi: 10.1007/s00586-018-5673-2. [DOI] [PubMed] [Google Scholar]
- 21.Chou R, Gordon DB, De Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131–157. doi: 10.1016/j.jpain.2015.12.008. [DOI] [PubMed] [Google Scholar]
- 22.Jermini-Gianinazzi I, Blum M, Trachsel M, Trippolini MA, Tochtermann N, Rimensberger C, et al. Management of acute non-specific low back pain in the emergency department: do emergency physicians follow the guidelines? Results of a cross-sectional. BMJ Open. 2023;13(8):e071893. doi: 10.1136/bmjopen-2023-071893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Hall AM, Scurrey SR, Pike AE, Albury C, Richmond HL, Matthews J, et al. Physician-reported barriers to using evidence-based recommendations for low back pain in clinical practice: a systematic review and synthesis of qualitative studies using the Theoretical Domains Framework. Implement Sci. 2019;14(1):49. doi: 10.1186/s13012-019-0884-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Haldeman S, Nordin M, Chou R, Côté P, Hurwitz EL, Johnson CD, et al. The Global Spine Care Initiative: World Spine Care executive summary on reducing spine-related disability in low- and middle-income communities. Eur Spine J. 2018;27(S6):776–785. doi: 10.1007/s00586-018-5722-x. [DOI] [PubMed] [Google Scholar]
- 25.Johnson CD, Haldeman S, Chou R, Nordin M, Green BN, Côté P, et al. The Global Spine Care Initiative: model of care and implementation. Eur Spine J. 2018;27(S6):925–945. doi: 10.1007/s00586-018-5720-z. [DOI] [PubMed] [Google Scholar]
- 26.Speerin R, Needs C, Chua J, Woodhouse LJ, Nordin M, McGlasson R, et al. Implementing models of care for musculoskeletal conditions in health systems to support value-based care. Best Pract Res Clin Rheumatol. 2020;34(5):101548. doi: 10.1016/j.berh.2020.101548. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Haldeman S, Johnson CD, Chou R, Nordin M, Côté P, Hurwitz EL, et al. The Global Spine Care Initiative: classification system for spine-related concerns. Eur Spine J. 2018;27(S6):889–900. doi: 10.1007/s00586-018-5724-8. [DOI] [PubMed] [Google Scholar]
- 28.Haldeman S, Johnson CD, Chou R, Nordin M, Côté P, Hurwitz EL, et al. The Global Spine Care Initiative: care pathway for people with spine-related concerns. Eur Spine J. 2018;27(S6):901–914. doi: 10.1007/s00586-018-5721-y. [DOI] [PubMed] [Google Scholar]
- 29.Bussières A, Passmore S, Kopansky-Giles D, Tavares P, Ward J, Ladwig J, et al. Assessing the readiness and feasibility to implement a model of care for spine disorders and related disability in Cross Lake, an Indigenous community in northern Manitoba, Canada: a research protocol. Chiropr Man Ther. 2025;33(1):12. doi: 10.1186/s12998-025-00576-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 30.Government of Canada. Indigenous Peoples and Communities; 2024. Indigenous Peoples and Communities. Available from: https://www.rcaanc-cirnac.gc.ca/eng/1100100013785/1529102490303. [Google Scholar]
- 31.Wu AM, Cross M, Elliott JM, Culbreth GT, Haile LM, Steinmetz JD, et al. Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2024;6(3):e142–155. doi: 10.1016/S2665-9913(23)00321-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Canadian Pain Task Force. Working together to better understand, prevent, and manage chronic pain: what we heard. Ottawa, ON: Health Canada = Santé Canada; 2020. Available from: https://www.canada.ca/content/dam/hc-sc/documents/corporate/about-health-canada/public-engagement/external-advisory-bodies/canadian-pain-task-force/report-2020-rapport/report-2020.pdf. [Google Scholar]
- 33.Hudson I, Cohen B. Manitoba Inequality Update. 2018. Jun, Available from: https://www.policyalternatives.ca/wp-content/uploads/attachments/Manitoba_Inequality_Update.pdf.
- 34.Ramsoondar N, Anawati A, Cameron E. Racism as a determinant of health and health care: Rapid evidence narrative from the SAFE for Health Institutions project. Can Fam Physician. 2023;69(9):594–598. doi: 10.46747/cfp.6909594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 35.Government of Canada. Report 4—Access to Health Services for Remote First Nations Communities [Internet] www.oag-bvg.gc.ca. 2015. [Accessed on 2025 Nov 22]. Available from: https://www.oag-bvg.gc.ca/internet/English/parl_oag_201504_04_e_40350.html.
- 36.Canadian Association for Rural & Remote Nursing (CARRN) Unpublished report. Ottawa: CARRN; 2020. [Accessed on 2025 Nov 22]. Rural and remote nursing practice in Canada: an updated discussion paper [Internet] Available from: https://www.carrn.com/images/pdf/CARRN_RR_discussion_doc_final_LR-2.pdf. [Google Scholar]
- 37.Nordin M, Randhawa K, Torres P, Yu H, Haldeman S, Brady O, et al. The Global Spine Care Initiative: a systematic review for the assessment of spine-related complaints in populations with limited resources and in low- and middle-income communities. Eur Spine J. 2018;27(S6):816–827. doi: 10.1007/s00586-017-5446-3. [DOI] [PubMed] [Google Scholar]
- 38.Green BN, Johnson CD, Haldeman S, Kane EJ, Clay MB, Griffith EA, et al. The Global Spine Care Initiative: public health and prevention interventions for common spine disorders in low- and middle-income communities. Eur Spine J. 2018;27(S6):838–850. doi: 10.1007/s00586-018-5635-8. [DOI] [PubMed] [Google Scholar]
- 39.Robak N, Broeckelmann E, Mior S, Atkinson-Graham M, Ward J, Scott M, et al. Views and perspectives toward implementing the Global Spine Care Initiative (GSCI) model of care, and related spine care program by the people in Cross Lake, Northern Manitoba, Canada: a qualitative study using the Theoretical Domain Framework (TDF) Implement Sci Commun. 2024;5(1):100. doi: 10.1186/s43058-024-00636-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Bussières A, Atkinson-Graham M, Ward J, Scott M, Moss J, Tavares P, et al. The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey. Prev Med Rep. 2025;49:102960. doi: 10.1016/j.pmedr.2024.102960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 41.Corcoran KL, Bastian LA, Gunderson CG, Steffens C, Brackett A, Lisi AJ. Association Between Chiropractic Use and Opioid Receipt Among Patients with Spinal Pain: A Systematic Review and Meta-analysis. Pain Med. 2019:pnz219. doi: 10.1093/pm/pnz219. [DOI] [PubMed] [Google Scholar]
- 42.Whedon JM, Kizhakkeveettil A, Toler AW, MacKenzie TA, Lurie JD, Hurwitz EL, et al. Initial Choice of Spinal Manipulative Therapy for Treatment of Chronic Low Back Pain Leads to Reduced Long-term Risk of Adverse Drug Events Among Older Medicare Beneficiaries. Spine. 2021;46(24):1714–1720. doi: 10.1097/BRS.0000000000004078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 43.Kazis LE, Ameli O, Rothendler J, Garrity B, Cabral H, McDonough C, et al. Observational retrospective study of the association of initial healthcare provider for new-onset low back pain with early and long-term opioid use. BMJ Open. 2019;9(9):e028633. doi: 10.1136/bmjopen-2018-028633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 44.National Institute of Neurological Disorders and Stroke. National Institute of Neurological Disorders and Stroke Fact Sheets. Bethesda (MD): National Institute of Neurological Disorders and Stroke; 2022. Low back pain fact sheet. Available from: https://www.ninds.nih.gov/sites/default/files/migrate-documents/low_back_pain_20-ns-5161_march_2020_508c.pdf. [Google Scholar]
- 45.Chou R, Qaseem A, Owens DK, Shekelle P for the Clinical Guidelines Committee of the American College of Physicians*. Diagnostic Imaging for Low Back Pain: Advice for High-Value Health Care From the American College of Physicians. Ann Intern Med. 2011 Feb 1;154(3):181–189. doi: 10.7326/0003-4819-154-3-201102010-00008. [DOI] [PubMed] [Google Scholar]
- 46.Maher C, Underwood M, Buchbinder R. Non-specific low back pain. The Lancet. 2017 Feb;389(10070):736–747. doi: 10.1016/S0140-6736(16)30970-9. [DOI] [PubMed] [Google Scholar]
- 47.Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A, et al. Spinal stenosis prevalence and association with symptoms: the Framingham Study. Spine J. 2009;9(7):545–550. doi: 10.1016/j.spinee.2009.03.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 48.Koes BW, van Tulder MW, Thomas S. Diagnosis and treatment of low back pain. BMJ. 2006;332(7555):1430–1434. doi: 10.1136/bmj.332.7555.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49.Henschke N, Maher CG, Refshauge KM, Herbert RD, Cumming RG, Bleasel J, et al. Prevalence of and screening for serious spinal pathology in patients presenting to primary care settings with acute low back pain. Arthritis & Rheumatism. 2009;60(10):3072–3080. doi: 10.1002/art.24853. [DOI] [PubMed] [Google Scholar]
- 50.Oldfield BJ, Gleeson B, Morford KL, Adams Z, Funaro MC, Becker WC, et al. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open. 2024;7(9):e2434835. doi: 10.1001/jamanetworkopen.2024.34835. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 51.Cashin AG, Folly T, Bagg MK, Wewege MA, Jones MD, Ferraro MC, et al. Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis. BMJ. 2021;374:n1446. doi: 10.1136/bmj.n1446. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 52.Ng JY, Mohiuddin U, Azizudin AM. Clinical practice guidelines for the treatment and management of low back pain: A systematic review of quantity and quality. Musculoskelet Sci Pract. 2021;51:102295. doi: 10.1016/j.msksp.2020.102295. [DOI] [PubMed] [Google Scholar]
- 53.Bussières A, Cancelliere C, Ammendolia C, Comer CM, Zoubi FA, Châtillon CE, et al. Non-Surgical Interventions for Lumbar Spinal Stenosis Leading To Neurogenic Claudication: A Clinical Practice Guideline. J Pain. 2021;22(9):1015–1039. doi: 10.1016/j.jpain.2021.03.147. [DOI] [PubMed] [Google Scholar]
- 54.Mathieson S, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, et al. Trial of Pregabalin for Acute and Chronic Sciatica. N Engl J Med. 2017;376(12):1111–1120. doi: 10.1056/NEJMoa1614292. [DOI] [PubMed] [Google Scholar]
- 55.Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, et al. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016;157(7):1499–1507. doi: 10.1097/j.pain.0000000000000554. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 56.Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. Drugs. 2021;81(1):125–156. doi: 10.1007/s40265-020-01432-7. [DOI] [PubMed] [Google Scholar]
- 57.Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, Van Den Brink W. Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. In: Tsai AC, editor. PLOS Med. 10. Vol. 14. 2017. p. e1002396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 58.Canadian Institute for Health Information. Opioid prescribing in Canada: how are practices changing? [Internet] Ottawa: CIHI; 2017. [Accessed on 2025 Nov 22]. Available from: https://www.cihi.ca/en/opioid-prescribingin-canada-how-are-practices-changing. [Google Scholar]
- 59.Belzak L, Halverson J. Evidence synthesis – The opioid crisis in Canada: a national perspective. Health Promot Chronic Dis Prev Can. 2018;38(6):224–233. doi: 10.24095/hpcdp.38.6.02. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 60.Busse JW, Craigie S, Juurlink DN, Buckley DN, Wang L, Couban RJ, et al. Guideline for opioid therapy and chronic noncancer pain. Can Med Assoc J. 2017;189(18):E659–666. doi: 10.1503/cmaj.170363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 61.Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, et al. Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis. JAMA. 2018;320(23):2448. doi: 10.1001/jama.2018.18472. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 62.Krebs EE, Gravely A, Nugent S, Jensen AC, DeRonne B, Goldsmith ES, et al. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. JAMA. 2018;319(9):872. doi: 10.1001/jama.2018.0899. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 63.Jones CMP, Day RO, Koes BW, Latimer J, Maher CG, McLachlan AJ, et al. Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial. The Lancet. 2023;402(10398):304–312. doi: 10.1016/S0140-6736(23)00404-X. [DOI] [PubMed] [Google Scholar]
- 64.National Institute on Drug Abuse. Overdose Death Rates. Available from: https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates?utm_source=chatgpt.com#Fig4.
- 65.Traeger A, Buchbinder R, Elshaug A, Croft P, Maher C. Care for low back pain: can health systems deliver? Bull World Health Organ. 2019;97(6):423–433. doi: 10.2471/BLT.18.226050. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 66.Passmore S, Ward J, Scott M, Tavares P, Kopansky-Giles D. Quality assurance report: Cross Lake Nursing Station Chiropractic Implementation Project (October 2023 – June 2025) World Spine Care Canada; 2025. Unpublished report. [Google Scholar]
- 67.Mior S, Wong J, Sutton D, Beliveau PJH, Bussières A, Hogg-Johnson S, et al. Understanding patient profiles and characteristics of current chiropractic practice: a cross-sectional Ontario Chiropractic Observation and Analysis STudy (O-COAST) BMJ Open. 2019;9(8):e029851. doi: 10.1136/bmjopen-2019-029851. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 68.Beliveau PJH, Wong JJ, Sutton DA, Simon NB, Bussières AE, Mior SA, et al. The chiropractic profession: a scoping review of utilization rates, reasons for seeking care, patient profiles, and care provided. Chiropr Man Ther. 2017;25(1):35. doi: 10.1186/s12998-017-0165-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 69.Fennelly O, Blake C, Desmeules F, Stokes D, Cunningham C. Patient-reported outcome measures in advanced musculoskeletal physiotherapy practice: a systematic review. Musculoskeletal Care. 2018;16(1):188–208. doi: 10.1002/msc.1200. [DOI] [PubMed] [Google Scholar]
- 70.Ryder C, Stephens JH, Ullah S, Coombes J, Cominos N, Sharpe P, et al. Community Engagement and Psychometric Methods in Aboriginal and Torres Strait Islander Patient-Reported Outcome Measures and Surveys—A Scoping Review and Critical Analysis. Int J Environ Res Public Health. 2022;19(16):10354. doi: 10.3390/ijerph191610354. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 71.Prinsen CAC, Mokkink LB, Bouter LM, Alonso J, Patrick DL, De Vet HCW, et al. COSMIN guideline for systematic reviews of patient-reported outcome measures. Qual Life Res. 2018;27(5):1147–1157. doi: 10.1007/s11136-018-1798-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 72.Krogsgaard MR, Hansen CF. Patient-reported outcome measures: it is time for authors, reviewers, journal editors and health care strategists to take sufficient responsibility. Knee Surg Sports Traumatol Arthrosc. 2022 Nov;30(11):3589–3593. doi: 10.1007/s00167-022-07138-5. [DOI] [PubMed] [Google Scholar]
- 73.Latimer M, Rudderham S, Harman K, Finley A, Dutcher L, Hutt-Macleod D, et al. Using Art as a Medium for First Nations Youth to Express Their Pain: A Two-Eyed Seeing Qualitative Study. Paediatr Child Health. 2016;21(Supplement_5):e94a–e94a. [Google Scholar]
- 74.Redvers N, Lokugamage AU, Barreto JPL, Bajracharya MB, Harris M. Epistemicide, health systems, and planetary health: Re-centering Indigenous knowledge systems. In: Robinson J, editor. PLOS Glob Public Health. 8. Vol. 4. 2024. p. e0003634. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 75.Crockett K, Lovo S, Irvine A, Trask C, Oosman S, McKinney V, et al. “Navigating chaos”: Urban, Rural, and Remote Patient Experiences in Accessing Healthcare with Indigenous and Non-Indigenous Perspectives of Living with Chronic Low Back Pain. Can J Pain. 2024;8(2):2318706. doi: 10.1080/24740527.2024.2318706. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 76.Canadian Pain Task Force. Chronic pain in Canada: laying a foundation for action: a report by the Canadian Pain Task Force. Ottawa (ON): Health Canada; Jun, 2019. 2019. [Google Scholar]
- 77.Zhang T, Bath B, McKinney V, Swidrovich J, Johnson R, Foulds H, et al. Understanding Needs for Chronic Musculoskeletal Pain Management in a Northern Dene and Métis Community: A Community Based Needs Assessment. Can J Pain. 2024;8(2):2412560. doi: 10.1080/24740527.2024.2412560. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 78.Julien N, Lacasse A, Labra O, Asselin H. Review of chronic non-cancer pain research among Aboriginal people in Canada. Int J Qual Health Care. 2018;30(3):178–185. doi: 10.1093/intqhc/mzx195. [DOI] [PubMed] [Google Scholar]
- 79.The First Nations Regional Health Survey. Ottawa, ON, CA: First Nations Information Governance Centre; 2018. Available at https://fnigc.ca/wp-content/uploads/2020/09/53b9881f96fc02e9352f7cc8b0914d7a_FNIGC_RHS-Phase-3-Volume-Two_EN_FINAL_Screen.pdf. [Google Scholar]
- 80.Corso M, DeSouza A, Brunton G, Yu H, Cancelliere C, Mior S, et al. Integrating Indigenous healing practices within collaborative care models in primary healthcare in Canada: a rapid scoping review. BMJ Open. 2022;12(6):e059323. doi: 10.1136/bmjopen-2021-059323. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 81.Shah N, Qazi R, Chu XP. Unraveling the tapestry of pain: A comprehensive review of ethnic variations, cultural influences, and physiological mechanisms in pain management and perception. [Accessed on 2025 Nov 22];Cureus [Internet] 2024 May 20;16(5) doi: 10.7759/cureus.60692. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186588/pdf/cureus-0016-00000060692.pdf. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 82.Allice I, Acai A, Ferdossifard A, Wekerle C, Kimber M. Indigenous Cultural Safety in Recognizing and Responding to Family Violence: A Systematic Scoping Review. Int J Environ Res Public Health. 2022;19(24):16967. doi: 10.3390/ijerph192416967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 83.Truth and Reconciliation Commission of Canada, 2012. Truth and Reconciliation Commission of Canada: Calls to Action. Available from: https://www2.gov.bc.ca/assets/gov/british-columbians-our-governments/indigenous-people/aboriginal-peoples-documents/calls_to_action_english2.pdf.
- 84.Maar MA, Shawande M. Traditional Anishinabe Healing in a Clinical Setting: The Development of an Aboriginal Interdisciplinary Approach to Community-based Aboriginal Mental Health Care. Int J Indig Health. 2013;6(1):18–27. [Google Scholar]
- 85.Hart-Wasekeesikaw F. Cultural competence and cultural safety in nursing education: a framework for First Nations, Inuit, and Métis nursing [Internet] Ottawa: Aboriginal Nurses Association of Canada; 2009. [Accessed on 2025 Nov 22]. Available from: https://www.cna-aiic.ca/-/media/cna/page-content/pdf-en/aboriginal_framework_e.pdf. [Google Scholar]
- 86.Baba L. Cultural Safety in First Nations, Inuit and Métis Public Health. 2013. Available from: https://www.ccnsa-nccah.ca/docs/emerging/RPT-CulturalSafetyPublicHealth-Baba-EN.pdf.
- 87.Sehgal A, Kennedy A, McGowan K, Crowshoe L., (Lindsay) Parallel systems in healthcare: Addressing Indigenous health equity in Canada. Glob Public Health. 2025;20(1):2452195. doi: 10.1080/17441692.2025.2452195. [DOI] [PubMed] [Google Scholar]
- 88.Moineau G. Caring for Canadians: Canada’s future health workforce: the Canadian health workforce education, training and distribution study. Ottawa, ON: Health Canada; 2025. [Google Scholar]
- 89.Asghari S, Kirkland M, Blackmore J, Boyd S, Farrell A, Rourke J, et al. A systematic review of reviews: Recruitment and retention of rural family physicians. Can J Rural Med. 2020;25(1):20. doi: 10.4103/CJRM.CJRM_4_19. [DOI] [PubMed] [Google Scholar]
- 90.Lafortune C, Gustafson J. Interventions to improve recruitment and retention of physicians in rural and remote Canada: A systematic review. [Accessed on 2025 Nov. 22];UWOMJ [Internet] 2019 Oct 27;88(1) Available from: https://ojs.lib.uwo.ca/index.php/uwomj/article/view/6184. [Google Scholar]
- 91.MacKay S, Smith A, Kyle R, Beattie M. What influences nurses’ decisions to work in rural and remote settings? A systematic review and meta-synthesis of qualitative research. Rural Remote Health [Internet] 2021. Mar 3, [Accessed on 2025 Nov 22]. Available from: https://www.rrh.org.au/journal/article/6335. [DOI] [PubMed]
- 92.Bailey NGN, Knott R, Grenier G, Craig KD, Kramer JLK. Physical pain among Indigenous Peoples in Canada: a scoping review. Can J Anesth Can Anesth. 2023;70(6):1047–1063. doi: 10.1007/s12630-023-02461-y. [DOI] [PubMed] [Google Scholar]



