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Inhibitory effects of garenoxacin and ciprofloxacin on wild-type and mutant (grlA) topoisomerase IV and wild-type gyrase
| Enzyme | Subunits
|
IC50
|
||||
|---|---|---|---|---|---|---|
| GrlA | GrlB | GyrA | GyrB | Garenoxacin | Ciprofloxacin | |
| Topoisomerase IV | Wild type | Wild type | 1.25-2.5 | 2.5-5.0 | ||
| Topoisomerase IV | Phe80 | Wild type | 125-250 | 250 | ||
| Gyrase | Wild type | Wild type | 1.25 | 10 | ||
