TABLE 1.
Sensitivity of mutants to avilamycina
| Strainb | IC50 (μg/ml)c |
|---|---|
| Wild type | <0.3 |
| U2470 | >66 |
| G2471 | >66 |
| C2471 | >66 |
| U2472 | 6.6 |
| C2478 | >66 |
| C2479 | >66 |
| U2480 | >66 |
| A2527 | >66 |
| C2528 | 6.6 |
| A2535 | 6.6 |
a
Growth was tested at the following concentrations of avilamycin: 0, 0.3, 1.3, 6.6, 13.2, 33, and 66 μg/ml.
b
The underlined mutations were obtained in this study by selection with avilamycin. Except for U2470 and C2472, all mutants were obtained by Belova et al. (7) by selection with evernimicin.
c
IC50, minimal concentrations of avilamycin where growth (measured by absorbance) was 50% or less of growth in the absence of antibiotic.