FIG. 3.

Survival of mice treated with PEN G (125 mg/kg s.c.) or OFX (40 mg/kg p.o.) for 21 days after ⁶⁰Co γ irradiation (7 Gy) and challenge with B. anthracis Sterne spores (3.3 × 10⁸ CFU i.t.). Therapy was started either 7.5 or 24 h after challenge. Significant comparisons were as follows: P < 0.01 for control versus PEN G started at 7.5 h, OFX started at 7.5 h, PEN G started at 24 h, and OFX started at 24 h.