FIG. 4.

Survival of B6D2F₁/J mice treated with antimicrobial agents (20 mg of TVA/kg p.o. or s.c., 40 mg of OFX/kg p.o., or 125 mg of PEN G/kg s.c.) for 21 days after ⁶⁰Co γ irradiation (7 Gy) and challenge with B. anthracis Sterne spores (4.1 × 10⁸ CFU i.t.). Therapy was started 24 h after challenge. Significant comparisons were as follows: P < 0.01 for control versus TVA s.c., TVA p.o., PEN G plus OFX, and OFX p.o., for PEN G plus OFX versus TVA p.o., and for PEN G + OFX versus TVA s.c.; P < 0.05 for control versus PEN G s.c., PEN G s.c. versus PEN G plus OFX, and OFX p.o. versus PEN G plus OFX.