Table 2:
List Long Non-coding RNAs associated with ubiquitination and proteasomal degradation.
| LncRNA (Chromosome location) |
Full name | Function in Ubiquitination and Proteasomal Degradation |
REF |
|---|---|---|---|
| H19 (11p15.5) | H19 Imprinted Maternally Expressed Transcript | Regulates HIF-1α | 237, 238, 240, 241 |
| UCA1 (19p13.12) | Urothelial Carcinoma Associated 1 | Regulates the stability of the tumor suppressor PTEN | 242, 243, 246, 251 |
| MALAT1 (11q13.1) | Metastasis Associated Lung Adenocarcinoma Transcript 1 | Modulates the expression and activity of E3 ubiquitin ligases | 252, 253, 261, 262 |
| HOTAIR (12q13.13) | HOX Transcript Antisense Intergenic RNA | Interacts with different E3 ligases to promote degradation of specific target proteins involved in cancer progression | 182, 224, 225, 230-233 |
| NEAT 1 (11q12.1) | Nuclear Enriched Abundant Transcript 1 | Might have functions in assembly of ubiquitin ligase and their substrates | 264-266 |
| HULC (6p24.3) | Highly Upregulated in Liver Cancer | Predicted to modify ubiquitination status of proteins | 295-297 |
| PVT1 (8q24.21) | Plasmacytoma variant translocation 1 | Prevents E3 ubiquitin ligase SKP2 from ubiquitination and proteasomal degradation | 282 |
| BACE1-AS (11q23.3) | BACE 1 Antisense RNA | Enhances proteasomal degradation by binding to miR-485-5p and increasing the expression of proteasomal subunit PSMB2 | 3, 4, 7, 33, 171 |
| LNC473 (6q27) | LINC00473 | Inhibits ubiquitination of survivin via deubiquitinase USP9X and thus enhances cell proliferation and invasion in hepatocellular carcinoma | 279 |
| PTENP1 (9p13.3) | Phosphatase and Tensin Homolog Pseudogene 1 | Acts as a sponge for some of the PTEN-targeting miRNAs and protects it from degradation | 319 |
| LINC00963/MetaLnc9 (9q34.11) | Long Intergenic Non-Protein Coding RNA 963 | It interacts with PGK1 kinase and prevents its ubiquitination, thereby fostering AKT/mTOR signalling | 320 |
| MEG3 (14q32.2) | Maternally Expressed 3 | Promotes the phosphorylation of EZH2 at Thr-345 and Thr-487, which lowers protein levels of EZH2 by promoting its ubiquitination and degradation | 321 |
| BDNF-AS (11p14.1) | Brain-Derived Neurotrophic Factor Antisense RNA | Promotes breast cancer progression by functioning as a scaffold RNA supporting RNH1 ubiquitination by the E3 ligase TRIM21 and thus RNH1 degradation which leads to cancer progression | 322 |