. Author manuscript; available in PMC: 2026 Feb 6.

Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2024 Sep 26;1867(4):195061. doi: 10.1016/j.bbagrm.2024.195061

Table 3:

MicroRNAs in Ubiquitination and Proteasomal Degradation

MicroRNA	Target	Mechanism	REF
miR-1	MuRF1, MAFbx	Induces MuRF1 and MAFbx expression via the HSP70/protein kinase B(Akt)/forkhead box (Fox) O3 signaling pathway. Cause of Dex-induced muscle atrophy	^{284, 289, 290}
miR-23a	MuRF1, MAFbx	Inhibits the translational activation of MuRF1 and MAFbx via binding with their 3′-UTR	^{284, 285, 288, 289, 291, 292}
miR-199/214 cluster	MuRF1, MAFbx	Regulation of atrophic gene expression in a PI3K/Akt/FoxO-dependent manner	^{288, 289, 291-293}
miR-182	Atrophic genes	Represses atrophic gene expression via inhibition of FoxO protein translation	^{284, 285, 288, 289, 291, 292}
miR-486	PTEN	Suppressing PTEN expression enhances PI3K/Akt activation and promotes FoxO phosphorylation. Phosphorylated FoxO is located in the cytoplasm and is degraded by the proteasome.	^{284, 285, 288, 289, 291, 292}
miR-71	ERAD	Promotes ubiquitin-dependent protein turnover to maintain proteostasis and longevity in nematodes	^{284, 285, 288, 289, 291, 292}
miR-30	HD	Inhibits ubiquitin complex binding with proteasome	^{288, 289}