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. 2005 Nov 29;3(12):e415. doi: 10.1371/journal.pbio.0030415

Figure 3. Effect of Pomc-Specific Tfam Deficiency on Pomc and Agrp Immunostaining.

Figure 3

Each column of panels shows coronal sections from a 7-mo-old control (Tfam flox/+; Tg.PomcCre/+ or Tfam flox/flox; +/+), Pomc-specific Tfam mutant (Tfam flox/flox; Tg.PomcCre/+), and Agrp-specific Tfam mutant (Tfam flox/flox; Tg.AgrpCre/+) on the left, middle, and right, respectively. Each section was stained for α-MSH or Agrp as indicated. The three lower panels show coronal sections stained to reveal cell nuclei (DAPI) and immunostained for GFAP, and indicate that ablation of Pomc or Agrp neurons does not grossly disturb tissue architecture, cell number, or stimulate astrocytosis. The sections shown are representative of three different animals that were examined.

IR, immmunoreactivity.