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. 2005 Nov 29;3(12):e423. doi: 10.1371/journal.pbio.0030423

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Copyright: © 2005 Mohler et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) 220-kDa ankyrin-B domain organization. The human LQT4 E1425G mutation is marked.

(B) Immunoblot of expressed wild-type and mutant GFP-ankyrin-B proteins.

(C–E) Relative binding of rat heart lysate (C) InsP₃R, (D) NCX1, and (E) NKA to wild-type and mutant GFP-ankyrin-B proteins. Bound NCX1, NKA, and InsP₃R were evaluated following quantitative immunoblot (pan-InsP₃R, pan-NKA, and NCX1 Ig) and phosphorimaging (n = 3, p < 0.05).