Table 2.

Summary of 42 Cases of t(11;22)

Case	Patient ID	Race	Associated Finding(s)
Carriers of balanced translocation:
Unaffected:
1a	CH99-200	White	No +der(22) in pedigree
2	CH97-82	White	+der(22) in twins; bilateral breast cancer
3a	CH97-62	White
4	CH92-224L	White
5	CH95-257	White
6	CH94-188L	White
7	P91-007F	White	Mosaic for t(11;22), 46,XX(20%)/46,XX,t(11;22)(80%)
8b	CH97-78	White	Carrier of de novo t(11;22)
9a	CH97-120	White
10	CH96-180	White
11	CH97-03	White
12c	CH97-181	White
13d	CH98-40	White
14	CH98-120	Hispanic
15	CH98-169	White
16	CH97-48	White	Carrier of de novo t(11;22)
17	CH91-221L	Lebanese
18	P89-43	White	Aunt of +der(22) meiosis II nondisjunction
19	CH96-123	White
20	CH00-09	White
21d	CH00-32	White
22	CH91-258L	White
23	CH93-075L	White	No +der(22) in pedigree
24	P90-34L	White
25	CH2227	White
26	D00-28	White
27	CH98-229	White
28	CH94-037L	White
29	CH2217	White
30	CH91-182L	White
31	CH92-360L	Hispanic
32e	GM03372	African American
33e	GM04403	White
34e	GM06229	White
35	IARC322	White
Abnormal phenotype:
36	CH91-150F	White	Carrier of balanced translocation who had holoprosencephaly
37	CH97-33	White	Carrier of balanced translocation who had an abnormal phenotype
38	P91-015L	White	Carrier of balanced translocation who had mental retardation, lactic acidosis, and autism
39	D97-309	White	Carrier of de novo translocation who had an abnormal phenotype
40	D98-78	White	Carrier of de novo translocation who had an abnormal phenotype
Supernumerary-der(22) syndrome:
41d	CH93-166L	Palestinian
42	D9-61	White	De novo +der(22)

^aReported in our previous work (Kurahashi et al. 2000).

^bPreviously reported by Zackai and Emanuel (1980), as “family C.”

^cPreviously reported by Zackai and Emanuel (1980), as “family B.”

^d+der(22) transmitted by a father who was a carrier.

^eObtained from Coriell Cell Repositories (Camden, NJ).