. Author manuscript; available in PMC: 2026 Feb 6.

Published in final edited form as: J Ethnopharmacol. 2025 Aug 6;353(Pt A):120361. doi: 10.1016/j.jep.2025.120361

Table 5.

The ZIP Synergy scores of the concomitant vs. pre-exposure MRME and MTX combinations.

	MCF-7 (ER+)		MDA-MB-231 (ER−)		MCF-10A (normal)
EXTRACT
	MTX	TAM	MTX	TAM	MTX	TAM
MRME	2.22 Additive	7.68 Additive	7.22 Additive	−1.79 Additive	16.75 Synergistic	−1.36 Additive
Pre-Treatment w/MRME	5.63 Additive ⬆	3.15 Additive ⬇	6.33 Additive ⬇	2.64 Additive ⬆	0.86 Additive ⬇	6.94 Additive ⬆

The red arrows indicate increases in synergy score and the green arrows indicate decrease in synergy score.